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PROW: CD100
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD100
Author: Laurence Boumsell
Reviewer: Gordon J. Freeman
[GUIDE BAR]

ALTERNATE NAMES FOR CD100  

MAJOR LINKS FOR CD100  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD100  

CELLULAR FUNCTION OF CD100  

DISEASE RELEVANCE OF CD100 AND FUNCTION OF CD100 IN INTACT ANIMAL   - No information


STRUCTURE
MOLECULAR FAMILY FOR CD100  

MOLECULAR STRUCTURE OF CD100   - Homodimer

MOLECULAR MASS OF CD100  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
PHA blasts 300kDa 150kDa  
Soluble form 120 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD100   - No information

POST-TRANSLATIONAL MODIFICATION OF CD100   - No information


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD100   - No information

SUBSTRATES FOR CD100   - No information

ENZYMES WHICH MODIFY CD100   - No information

LIGANDS FOR CD100 AND MOLECULES ASSOCIATED WITH CD100  

MOLECULECOMMENT
CD45 PTPase
Serine kinase activity  

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD100  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD100   - No information


REAGENTS
CD100-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
133.1C6 (NL-026) Villella  
196.48 (NL-037) Villela  

SELECTION OF OTHER CD100-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
BB18 (NL-056) Boumsell  
BD16 (NL-057) Boumsell  
A8 (NL-014) Aversa  
F937G2 Carriere  
148-2D12 Villela  

 
SELECTED REFERENCES ON CD100  

REVIEWS

PRIMARY CITATIONS

1. Bougeret C,Mansur IG,Dastot H,Schmid M,Mahouy G,Bensussan A,Boumsell L Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation. J Immunol 1992 148:318 PubMed

2. Hall KT,Boumsell L,Schultze JL,Boussiotis VA,Dorfman DM,Cardoso AA,Bensussan A,Nadler LM,Freeman GJ Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci U S A 1996 93:11780 PubMed

3. Herold C, Dastot H, Bensussan A, and Boumsell L (1995). In Leucocyte Typing V, Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R, Springer T, Tedder TF, and Todd RF eds. Oxford University Press, Oxford. 288-289.

4. Herold C, Dastot H, Bismuth G, Bensussan A, and Boumsell L (1995). In Leucocyte Typing V, Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R, Springer T, Tedder TF, and Todd RF eds. Oxford University Press, Oxford. 290-292.

5. Herold C, Elhabazi A, Bismuth G, Bensussan A, and Boumsell L. J Immunol in press.

6. Herold C,Bismuth G,Bensussan A,Boumsell L Activation signals are delivered through two distinct epitopes of CD100, a unique 150 kDa human lymphocyte surface structure previously defined by BB18 mAb. Int Immunol 1995 7:1 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov