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PROW: CD58
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD58
Author: Eiji Takeuchi
Reviewer: Timothy A. Springer
[GUIDE BAR]

ALTERNATE NAMES FOR CD58  

MAJOR LINKS FOR CD58  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD58   - Ligand for CD2

CELLULAR FUNCTION OF CD58  

DISEASE RELEVANCE OF CD58 AND FUNCTION OF CD58 IN INTACT ANIMAL   - Unknown


STRUCTURE
MOLECULAR FAMILY FOR CD58  

MOLECULAR STRUCTURE OF CD58  

MOLECULAR MASS OF CD58  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
JY   55-70 kDa  
Erythrocyte   40-70 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD58  

POST-TRANSLATIONAL MODIFICATION OF CD58  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD58   - Unknown

SUBSTRATES FOR CD58   - Unknown

ENZYMES WHICH MODIFY CD58   - Unknown

LIGANDS FOR CD58 AND MOLECULES ASSOCIATED WITH CD58  

MOLECULECOMMENT
CD2 CD2 is the only known receptor for CD58

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD58  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD58   - No information


REAGENTS
CD58-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
MEM63 (A047) V Horejsi, Praha  

SELECTION OF OTHER CD58-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
TS2/9 Sanchez-Madrid F et al. 1982  
AICD58 Immunotech  
BRIC5 Anstee  

 
SELECTED REFERENCES ON CD58  

REVIEWS

1. Springer TA,Dustin ML,Kishimoto TK,Marlin SD The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. Annu Rev Immunol 1987 5:223 PubMed

PRIMARY CITATIONS

2. Arulanandam AR,Kister A,McGregor MJ,Wyss DF,Wagner G,Reinherz EL Interaction between human CD2 and CD58 involves the major beta sheet surface of each of their respective adhesion domains. J Exp Med 1994 180:1861 PubMed

3. Dustin ML,Selvaraj P,Mattaliano RJ,Springer TA Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface. Nature 1987 329:846 PubMed

4. Osborn L,Day ES,Miller GT,Karpusas M,Tizard R,Meuer SC,Hochman PS Amino acid residues required for binding of lymphocyte function- associated antigen 3 (CD58) to its counter-receptor CD2. J Exp Med 1995 181:429 PubMed

5. Plunkett ML,Sanders ME,Selvaraj P,Dustin ML,Springer TA Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3). J Exp Med 1987 165:664 PubMed

6. Sanchez-Madrid F,Krensky AM,Ware CF,Robbins E,Strominger JL,Burakoff SJ,Springer TA Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A 1982 79:7489 PubMed

7. Sanders ME,Makgoba MW,Sharrow SO,Stephany D,Springer TA,Young HA,Shaw S Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. J Immunol 1988 140:1401 PubMed

8. Seed B An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2. Nature 1987 329:840 PubMed

9. Semnani RT,Nutman TB,Hochman P,Shaw S,van Seventer GA Costimulation by purified intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 induces distinct proliferation, cytokine and cell surface antigen profiles in human 'naive' and 'memory' CD4+ T cells. J Exp Med 1994 180:2125 PubMed

10. Wallner BP,Frey AZ,Tizard R,Mattaliano RJ,Hession C,Sanders ME,Dustin ML,Springer TA Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein. J Exp Med 1987 166:923 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov