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PROW: CD126
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD126
Authors: Tetsuya Taga; Atsushi Kumanogo
Reviewer: Stefan Rose-John
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD126  

MAJOR LINKS FOR CD126  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD126   - No biochemical activity shown

CELLULAR FUNCTION OF CD126  

DISEASE RELEVANCE OF CD126 AND FUNCTION OF CD126 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD126  

MOLECULAR STRUCTURE OF CD126  

MOLECULAR MASS OF CD126  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
T cells, monocytes, hepatocytes etc* 80 kDa 80 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD126  

POST-TRANSLATIONAL MODIFICATION OF CD126  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD126   - Not known

SUBSTRATES FOR CD126  

ENZYMES WHICH MODIFY CD126  

MOLECULECOMMENT
Unknown metalloprotease Attacks CD126 and produces a biologically active extracellular soluble form *

LIGANDS FOR CD126 AND MOLECULES ASSOCIATED WITH CD126  

MOLECULECOMMENT
Interleukin-6 The only known ligand for CD126
CD130 (gp130) CD126 associates with gp130 (CD130) after binding to interleukin-6*

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD126  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD126  
REAGENTS
CD126-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
M11 (C-03) Brochier  
M5 (C-63) Brochier  

SELECTION OF OTHER CD126-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
PM1 (C-091) Hirata et al., 1989 Reference mAb at 5th and 6th IWHLDA
MT18 (C-092) Hirata et al., 1989 Reference mAb at 5th and 6th IWHLDA
B-N12 (C-074R) Wijdenes Assigned at 5th IWHLDA and ref mAb at 6th IWHLDA
B-F19 (C-075R) Wijdenes Assigned at 5th IWHLDA and ref mAb at 6th IWHLDA
B-R6 (C-076R) Wijdenes Assigned at 5th IWHLDA and ref mAb at 6th IWHLDA
M91 (C-085R) Brochier Assigned at 5th IWHLDA and ref mAb at 6th IWHLDA
M164 (C-086R) Brochier Assigned at 5th IWHLDA and ref mAb at 6th IWHLDA
M182 (C-087R) Brochier Assigned at 5th IWHLDA and ref mAb at 6th IWHLDA
M195 (C-088R) Brochier Assigned at 5th IWHLDA and ref mAb at 6th IWHLDA

 
SELECTED REFERENCES ON CD126 Link to additional info in FORUM  

REVIEWS

1. Rose-John S,Heinrich PC Soluble receptors for cytokines and growth factors: generation and biological function. Biochem J 1994 300:281 ** PubMed

2. Taga T,Kishimoto T Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997 15:797 PubMed

PRIMARY CITATIONS

3. Hirata Y,Taga T,Hibi M,Nakano N,Hirano T,Kishimoto T Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies. J Immunol 1989 143:2900 PubMed

4. Mackiewicz A,Schooltink H,Heinrich PC,Rose-John S Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins. J Immunol 1992 149:2021 ** PubMed

5. Mullberg J,Schooltink H,Stoyan T,Gunther M,Graeve L,Buse G,Mackiewicz A,Heinrich PC,Rose-John S The soluble interleukin-6 receptor is generated by shedding. Eur J Immunol 1993 23:473 ** PubMed

6. Peters M,Jacobs S,Ehlers M,Vollmer P,Mullberg J,Wolf E,Brem G,Meyer zum Buschenfelde KH,Rose-John S The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL- 6 and prolongation of the plasma half-life of IL-6. J Exp Med 1996 183:1399 ** PubMed

7. Peters M,Schirmacher P,Goldschmitt J,Odenthal M,Peschel C,Fattori E,Ciliberto G,Dienes HP,Meyer zum Buschenfelde KH,Rose-John S Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice. J Exp Med 1997 185:755 ** PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov