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PROW: CD81
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD81
Author: Margaret Jones
Reviewer: Thomas F. Tedder
[GUIDE BAR]

ALTERNATE NAMES FOR CD81  

MAJOR LINKS FOR CD81  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD81   - No information

CELLULAR FUNCTION OF CD81  

DISEASE RELEVANCE OF CD81 AND FUNCTION OF CD81 IN INTACT ANIMAL   - Regulation of cell growth


STRUCTURE
MOLECULAR FAMILY FOR CD81  

MOLECULAR STRUCTURE OF CD81  

MOLECULAR MASS OF CD81  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
B cells 26 kDa    
Jurkat 26 kDa    
K562 cells 26 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD81   - No information

POST-TRANSLATIONAL MODIFICATION OF CD81   - No information


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD81   - No information

SUBSTRATES FOR CD81   - No information

ENZYMES WHICH MODIFY CD81   - No information

LIGANDS FOR CD81 AND MOLECULES ASSOCIATED WITH CD81  

MOLECULECOMMENT
Leu-13/9-29 See note 1
CD19 See note 1
CD21 See note 1

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD81  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD81  
REAGENTS
CD81-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
I.3.3.22 (CD81.1) Vilella  

SELECTION OF OTHER CD81-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
1D6 Leucocyte Typing V (1996)  
5A6 Leucocyte Typing V (1996)  
JS64 Leucocyte Typing V (1996)  
JS81 Leucocyte Typing V (1996)  
4TM-1 Leucocyte Typing V (1996)  

 
SELECTED REFERENCES ON CD81  

REVIEWS

PRIMARY CITATIONS

1. Andria ML,Hsieh CL,Oren R,Francke U,Levy S Genomic organization and chromosomal localization of the TAPA-1 gene. J Immunol 1991 147:1030 PubMed

2. Bradbury LE,Goldmacher VS,Tedder TF The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13. J Immunol 1993 151:2915 PubMed

3. Bradbury LE,Kansas GS,Levy S,Evans RL,Tedder TF The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J Immunol 1992 149:2841 PubMed

4. Bradbury, L. and Tedder, T.F. In Leucocyte Typing V (ed S. Schlossman et al) 690-691 Oxford University Press, Oxford (1995).

5. Freedman, A., Phifer, J.S. and Svahn, J. In Leucocyte Typing V (ed S. Schlossman et al) p732-733 Oxford University Press, Oxford (1995)

6. Oren R,Takahashi S,Doss C,Levy R,Levy S TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol Cell Biol 1990 10:4007 PubMed

7. Schick MR,Nguyen VQ,Levy S Anti-TAPA-1 antibodies induce protein tyrosine phosphorylation that is prevented by increasing intracellular thiol levels. J Immunol 1993 151:1918 PubMed

8. Takahashi S,Doss C,Levy S,Levy R TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen. J Immunol 1990 145:2207 PubMed

9. Tedder, T.F., Wagner, N. and Engel, P. in Leucocyte Typing V ed. Schlossman et al. (1996)

10. Vaickus L,Levy R Antiproliferative monoclonal antibodies: detection and initial characterization. J Immunol 1985 135:1987 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov