Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD62P
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD62P
Author: Piet W. Modderman
Reviewer: Denisa D. Wagner
[GUIDE BAR]

ALTERNATE NAMES FOR CD62P  

MAJOR LINKS FOR CD62P  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD62P   - No information

CELLULAR FUNCTION OF CD62P  

DISEASE RELEVANCE OF CD62P AND FUNCTION OF CD62P IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD62P  

MOLECULAR STRUCTURE OF CD62P  

MOLECULAR MASS OF CD62P  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Platelets 120 kDa 140 kDa  
Endothelial cells 120 kDa 140 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD62P  

POST-TRANSLATIONAL MODIFICATION OF CD62P  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD62P  
MOLECULECOMMENT
NF-kB/Rel p50 Pan and McEver: J.Biol.Chem. 1995:270:23077-23083
p52 homodimers Pan and McEver: J.Biol.Chem. 1995:270:23077-23083
IkBalfa-related inhibitor Bcl-3 Pan and McEver: J.Biol.Chem. 1995:270:23077-23083

SUBSTRATES FOR CD62P   - No information

ENZYMES WHICH MODIFY CD62P   - No information

LIGANDS FOR CD62P AND MOLECULES ASSOCIATED WITH CD62P  

MOLECULECOMMENT
CD162 (PSGL-1)(P-selectin glycoprotein ligand -1) a 240 kDa homodimeric (disulfide-linked) ligand for CD62P present on most myeloid cells, as well as on subsets of lymphocytes. Other lymphocytes contain nonfunctional forms of PSGL-1
CD24 found on human myeloid and tumor cells

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD62P  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD62P  
REAGENTS
CD62P-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
1E3 (P-43) Ault, South Portland  
AK-4 (P-44) Favaloro, Westmead  
GA6 (P-45) Becton Dickinson  

SELECTION OF OTHER CD62P-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
AC1.2 Furie, Boston**  
G1 McEver, Oklahoma City  
S12 McEver, Oklahoma City  
AK-6 Favaloro, Westmead  
C2 (CLB-tromb/6) Von dem Borne, Amsterdam  
RUU-SP1.18 Nieuwenhuis, Utrecht  

 
SELECTED REFERENCES ON CD62P  

REVIEWS

1. McEver RP,Moore KL,Cummings RD Leukocyte trafficking mediated by selectin-carbohydrate interactions. J Biol Chem 1995 270:11025 PubMed

2. Varki A Selectin ligands. Proc Natl Acad Sci U S A 1994 91:7390 PubMed

PRIMARY CITATIONS

3. Crovello CS,Furie BC,Furie B Histidine phosphorylation of P-selectin upon stimulation of human platelets: a novel pathway for activation-dependent signal transduction. Cell 1995 82:279 PubMed

4. Diacovo TG,Puri KD,Warnock RA,Springer TA,von Andrian UH Platelet-mediated lymphocyte delivery to high endothelial venules. Science 1996 273:252 PubMed

5. Frenette PS,Johnson RC,Hynes RO,Wagner DD Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc Natl Acad Sci U S A 1995 92:7450 ** PubMed

6. Frenette PS,Mayadas TN,Rayburn H,Hynes RO,Wagner DD Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell 1996 84:563 PubMed

7. Fujimoto T,Stroud E,Whatley RE,Prescott SM,Muszbek L,Laposata M,McEver RP P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage. J Biol Chem 1993 268:11394 PubMed

8. Johnston GI,Cook RG,McEver RP Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. Cell 1989 56:1033 PubMed

9. Mayadas TN,Johnson RC,Rayburn H,Hynes RO,Wagner DD Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 1993 74:541 PubMed

10. Norman KE,Moore KL,McEver RP,Ley K Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand- Blood 1995 86:4417 PubMed

11. Pan J,McEver RP Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-kappa B/Rel family. J Biol Chem 1995 270:23077 PubMed

12. Sako D,Chang XJ,Barone KM,Vachino G,White HM,Shaw G,Veldman GM,Bean KM,Ahern TJ,Furie B,et al Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 1993 75:1179 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov