The transcriptional cis-acting (DNA) elements have been identified by numerous authors. These sites have been defined by DH site analysis as well as extensive investigation into the precise DNA sequence involved in the control of CD4. Some of the transcription factors that control CD4 have also been identified. These include the Ets and Myb proteins which act on the promoter, and HEB, TCF-1 alpha/LEF-1, and E12-related proteins which act on the 5' enhancer. An enhancer exists 13.5 kb 5' of the murine CD4 promoter and 6 kb 5' of the human CD4 promoter. Another enhancer is present within the first intron. Two silencers exist within the first intron. The region between the promoter and the 5' enhancer has a negative effect on transcription from the CD4 promoter. The transcriptional start sites have been defined and the human and murine promoters have been partially characterized.
Sands JF and Nikolic-Zugic J. T cell-specific protein-DNA interactions occurring at the CD4 locus: identification of possible transcriptional control elements of the murine CD4 gene. Int. Immunol. 1992 4:1183 PubMed
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