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PROW: CD4
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PROW and IWHLDA present the GUIDE on:
CD4
Author: Dominique Piatier-Tonneau
Reviewer: Quentin Sattentau
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD4  

MAJOR LINKS FOR CD4  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD4   - No information

CELLULAR FUNCTION OF CD4  

DISEASE RELEVANCE OF CD4 AND FUNCTION OF CD4 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD4  

MOLECULAR STRUCTURE OF CD4  

MOLECULAR MASS OF CD4  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
T lymphocytes 55 kDa 55 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD4   - No alternate splicing

POST-TRANSLATIONAL MODIFICATION OF CD4   - Two N-linked glycosylations


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD4 Link to additional info in FORUM   - No information

SUBSTRATES FOR CD4   - No information

ENZYMES WHICH MODIFY CD4   - No information

LIGANDS FOR CD4 AND MOLECULES ASSOCIATED WITH CD4  

MOLECULECOMMENT
MHC class II molecules (2) Extracellular ligand for CD4
HIV envelope glycoprotein (gp120) (5) Extracellular ligand for CD4
IL-16 (1) Extracellular ligand for CD4
Human seminal plasma glycoprotein gp17/ Secretory actin-binding protein (SABP)/ Prolactin-inducible protein (PIP)/ Gross cystic disease fluid protein-15 (GCDFP-15) / Extra-parotid glycoprotein (EP-GP) (6) Extracellular ligand for CD4
p56lck (2,3) Protein tyrosine kinase, intracellular ligand for CD4

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD4  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD4  
REAGENTS
CD4-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
HI T4a (6T-001) D Cheng Shen  
HI T4b (6T-002) D Cheng Shen  
LT4 (6T-010) Alexander V Filatov  
MEM-16 (6T-013) Vaclav Horejsi  
IP 34 (6T-017) Armand Bensussan  
193-19 (6T-027) Ramon Vilella  
Anti-CD4 (6T-034) Zhu Li Ping  
L3 (6T-035) Kokichi Kikuchi  
RPA-T4 (6T-079) G Aversa  
OKT4A (6T-084) MC Connelly  
R2B7 (6T-086) KA Foster  
8F4 (6T-087) KA Foster  
LT4 [KK] (6T-091) K Koubek  

SELECTION OF OTHER CD4-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
NU-TH/1 K Sagawa  
LEU3a Becton Dickinson, USA  
Bl4 J Brochier - Immunotech, SA, France  
RPA-T4 G Aversa - Pharmingen, USA  
OKT4 P Rao - Ortho Diagnostic Systems, Inc., USA  

 
SELECTED REFERENCES ON CD4  

REVIEWS

1. Center DM,Kornfeld H,Cruikshank WW Interleukin 16 and its function as a CD4 ligand. Immunol Today 1996 17:476 PubMed

2. Gaubin M,Autiero M,Houlgatte R,Basmaciogullari S,Auffray C,Piatier-Tonneau D Molecular basis of T lymphocyte CD4 antigen functions. Eur J Clin Chem Clin Biochem 1996 34:723 PubMed

3. Kisielow P,von Boehmer H Development and selection of T cells: facts and puzzles. Adv Immunol 1995 58:87 PubMed

4. Mazerolles F,Auffray C,Fischer A Down regulation of T-cell adhesion by CD4. Hum Immunol 1991 31:40 PubMed

5. Sattentau QJ,Weiss RA The CD4 antigen: physiological ligand and HIV receptor. Cell 1988 52:631 PubMed

PRIMARY CITATIONS

6. Autiero M,Cammarota G,Friedlein A,Zulauf M,Chiappetta G,Dragone V,Guardiola J A 17-kDa CD4-binding glycoprotein present in human seminal plasma and in breast tumor cells. Eur J Immunol 1995 25:1461 PubMed

7. Brady RL,Dodson EJ,Dodson GG,Lange G,Davis SJ,Williams AF,Barclay AN Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2- terminal domains. Science 1993 260:979 PubMed

8. Moir S,Perreault J,Poulin L Postbinding events mediated by human immunodeficiency virus type 1 are sensitive to modifications in the D4-transmembrane linker region of CD4. J Virol 1996 70:8019 PubMed

9. Ryu SE,Kwong PD,Truneh A,Porter TG,Arthos J,Rosenberg M,Dai XP,Xuong NH,Axel R,Sweet RW,et al Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature 1990 348:419 PubMed

10. Sakihama T,Smolyar A,Reinherz EL Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120. Proc Natl Acad Sci U S A 1995 92:6444 PubMed

11. Wang JH,Yan YW,Garrett TP,Liu JH,Rodgers DW,Garlick RL,Tarr GE,Husain Y,Reinherz EL,Harrison SC Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature 1990 348:411 PubMed

12. Zhang, X., D. Piatier-Tonneau, C. Auffray, R. Murali, A. Mahapatra, F. Zhang, C. C. Maier, H. Saragovi, and M. I. Greene. 1996. Nature Biotechnology 14: 472-475.

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/14/99   mpr@mail.nih.gov