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PROW: CD23
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD23
Authors: Marika Sarfati; Guy Delespesse
Reviewer: JY Bonnefoy
[GUIDE BAR]

ALTERNATE NAMES FOR CD23  

MAJOR LINKS FOR CD23  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD23   - No information

CELLULAR FUNCTION OF CD23  

DISEASE RELEVANCE OF CD23 AND FUNCTION OF CD23 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD23  

MOLECULAR STRUCTURE OF CD23  

MOLECULAR MASS OF CD23  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
B cell, monocytes 45 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD23  

POST-TRANSLATIONAL MODIFICATION OF CD23  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD23   - Not known

SUBSTRATES FOR CD23   - No information

ENZYMES WHICH MODIFY CD23   - No information

LIGANDS FOR CD23 AND MOLECULES ASSOCIATED WITH CD23  

MOLECULECOMMENT
IgE  
CD21  
CD11b  
CD11c  

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD23  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD23  
REAGENTS
CD23-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
9P25 Immunotech, Marseille  
BU38 DL Hardie, Birmingham  

SELECTION OF OTHER CD23-SPECIFIC REFERENCE MAB   - No information


 
SELECTED REFERENCES ON CD23  

REVIEWS

PRIMARY CITATIONS

1. Delespesse G,Sarfati M,Wu CY,Fournier S,Letellier M The low-affinity receptor for IgE. Immunol Rev 1992 125:77 PubMed

2. Lamers MC,Yu P Regulation of IgE synthesis. Lessons from the study of IgE transgenic and CD23-deficient mice. Immunol Rev 1995 148:71 PubMed

3. Ludin C,Hofstetter H,Sarfati M,Levy CA,Suter U,Alaimo D,Kilchherr E,Frost H,Delespesse G Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor. EMBO J 1987 6:109 PubMed

4. Kikutani H,Inui S,Sato R,Barsumian EL,Owaki H,Yamasaki K,Kaisho T,Uchibayashi N,Hardy RR,Hirano T,et al Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell 1986 47:657 PubMed

5. Flores-Romo L,Shields J,Humbert Y,Graber P,Aubry JP,Gauchat JF,Ayala G,Allet B,Chavez M,Bazin H,et al Inhibition of an in vivo antigen-specific IgE response by antibodies to CD23. Science 1993 261:1038 PubMed

6. Aubry JP,Pochon S,Graber P,Jansen KU,Bonnefoy JY CD21 is a ligand for CD23 and regulates IgE production. Nature 1992 358:505 PubMed

7. Armant M,Ishihara H,Rubio M,Delespesse G,Sarfati M Regulation of cytokine production by soluble CD23: costimulation of interferon gamma secretion and triggering of tumor necrosis factor alpha release. J Exp Med 1994 180:1005 PubMed

8. Lecoanet-Henchoz S,Gauchat JF,Aubry JP,Graber P,Life P,Paul-Eugene N,Ferrua B,Corbi AL,Dugas B,Plater-Zyberk C,et al CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18. Immunity 1995 3:119 PubMed

9. Plater-Zyberk C,Bonnefoy JY Marked amelioration of established collagen-induced arthritis by treatment with antibodies to CD23 in vivo. Nat Med 1995 1:781 PubMed

10. Yu P,Kosco-Vilbois M,Richards M,Kohler G,Lamers MC Negative feedback regulation of IgE synthesis by murine CD23. Nature 1994 369:753 PubMed

11. Fujiwara H,Kikutani H,Suematsu S,Naka T,Yoshida K,Yoshida K,Tanaka T,Suemura M,Matsumoto N,Kojima S,et al The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A 1994 91:6835 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov