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PROW: CD54
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PROW and IWHLDA present the GUIDE on:
CD54
Authors: Kozoh Imai; Masayuki Tsujisaki
Reviewer: Timothy A. Springer
[GUIDE BAR]

ALTERNATE NAMES FOR CD54  

MAJOR LINKS FOR CD54  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD54   - No information

CELLULAR FUNCTION OF CD54  

DISEASE RELEVANCE OF CD54 AND FUNCTION OF CD54 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD54  

MOLECULAR STRUCTURE OF CD54  

MOLECULAR MASS OF CD54  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Lymphocytes 90 kDa 95 kDa?**  
Solid tumor cells 75-115 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD54   - No information

POST-TRANSLATIONAL MODIFICATION OF CD54   - No information


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD54  
MOLECULECOMMENT
AP-1 sites  

SUBSTRATES FOR CD54   - No information

ENZYMES WHICH MODIFY CD54   - No information

LIGANDS FOR CD54 AND MOLECULES ASSOCIATED WITH CD54  

MOLECULECOMMENT
CD11a/CD18 (LFA-1)  
CD11b/CD18 (Mac-1)  
Rhinovirus  
Unknown molecule on Plasmodium falciparum-infected erythrocytes  

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD54  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD54  
REAGENTS
CD54-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
6.5B5 (A031) Askaa  
D8H10 (A037) Fainboim  
MEM101A (A048) Horejsi  
MEM111 (A049) Horejsi  
MEM112 (A050) Horejsi  
B-H17 (A058) Desroches / Wijdenes  
B-H19 (A059) Desroches /Wijdenes  
B-H22 (A060) Desroches /Wijdenes  
B.R11 (A073) Desroches /Wijdenes  
AZN-ICM1.1 (A084) van Kooyk  
HA58 (A095) Antoinette Reyes, Tsujisaki / Imai (Ref. No. 9)  

SELECTION OF OTHER CD54-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
RR1/1 (A027) Rothlein R  

 
SELECTED REFERENCES ON CD54  

REVIEWS

1. Springer TA Adhesion receptors of the immune system. Nature 1990 346:425 PubMed

2. Dustin ML,Staunton DE,Springer TA Supergene families meet in the immune system. Immunol Today 1988 9:213 PubMed

PRIMARY CITATIONS

3. Simmons D,Makgoba MW,Seed B ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 1988 331:624 PubMed

4. Caras IW,Davitz MA,Rhee L,Weddell G,Martin DW Jr,Nussenzweig V Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. Nature 1987 325:545 PubMed

5. Medof ME,Lublin DM,Holers VM,Ayers DJ,Getty RR,Leykam JF,Atkinson JP,Tykocinski ML Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement. Proc Natl Acad Sci U S A 1987 84:2007 PubMed

6. Coyne KE,Hall SE,Thompson S,Arce MA,Kinoshita T,Fujita T,Anstee DJ,Rosse W,Lublin DM Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor. J Immunol 1992 149:2906 PubMed

7. Rothlein R,Dustin ML,Marlin SD,Springer TA A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 1986 137:1270 PubMed

8. Dustin ML,Rothlein R,Bhan AK,Dinarello CA,Springer TA Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 1986 137:245 PubMed

9. Tsujisaki M,Imai K,Hirata H,Hanzawa Y,Masuya J,Nakano T,Sugiyama T,Matsui M,Hinoda Y,Yachi A Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases. Clin Exp Immunol 1991 85:3 PubMed

10. Yamamura M,Hinoda Y,Sasaki S,Tsujisaki M,Oriuchi N,Endo K,Imai K A human/mouse chimeric monoclonal antibody against intercellular adhesion molecule-1 for tumor radioimmunoimaging. Jpn J Cancer Res 1996 87:405 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov