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PROW: CD42b
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD42b
Authors: Masja de Haas; Albert von dem Borne
Reviewer: Kenneth J. Clemetson
[GUIDE BAR]

ALTERNATE NAMES FOR CD42b  

MAJOR LINKS FOR CD42b  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD42b  

CELLULAR FUNCTION OF CD42b  

DISEASE RELEVANCE OF CD42b AND FUNCTION OF CD42b IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD42b  

MOLECULAR STRUCTURE OF CD42b  

MOLECULAR MASS OF CD42b  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Platelets 160 kDa 145 kDa (+24, GPIb beta)  

POST-TRANSCRIPTIONAL MODIFICATION OF CD42b   - No information

POST-TRANSLATIONAL MODIFICATION OF CD42b  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD42b  
MOLECULECOMMENT
GATA-1  
Ets  

SUBSTRATES FOR CD42b   - No information

ENZYMES WHICH MODIFY CD42b  

MOLECULECOMMENT
Calpain  
Elastase  
Cathepsin G  
Plasminogen  

LIGANDS FOR CD42b AND MOLECULES ASSOCIATED WITH CD42b  

MOLECULECOMMENT
CD42c CD42b forms a disulfide-linked heterodimer with CD42c
CD42a CD42b is non covalently linked with CD42a
CD42d CD42b is non covalently linked with CD42d
Actin binding protein (filamin) CD42b is the binding site in the complex for actin binding protein (filamin) via the cytoplasmic region
14-3-3 zeta protein CD42b is the binding site in the complex for 14-3-3 zeta protein via the C-terminal region of the cytoplasmic region**

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD42b  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD42b   - No information


REAGENTS
CD42b-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - None

SELECTION OF OTHER CD42b-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
MB45 Von dem Borne, Amsterdam  
AN-51 McMichael, Oxford  
AK-2 Favaloro, Westmead  

 
SELECTED REFERENCES ON CD42b  

REVIEWS

PRIMARY CITATIONS

1. Clemetson KJ,McGregor JL,James E,Dechavanne M,Luscher EF Characterization of the platelet membrane glycoprotein abnormalities in Bernard-Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis. J Clin Invest 1982 70:304 PubMed

2. Fox JE,Aggerbeck LP,Berndt MC Structure of the glycoprotein Ib.IX complex from platelet membranes. J Biol Chem 1988 263:4882 PubMed

3. Kuijpers RW,Ouwehand WH,Bleeker PM,Christie D,von dem Borne AE Localization of the platelet-specific HPA-2 (Ko) alloantigens on the N- terminal globular fragment of platelet glycoprotein Ib alpha. Blood 1992 79:283 PubMed

4. Lopez JA,Chung DW,Fujikawa K,Hagen FS,Papayannopoulou T,Roth GJ Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2- glycoprotein. Proc Natl Acad Sci U S A 1987 84:5615 PubMed

5. Miller JL,Castella A Platelet-type von Willebrand's disease: characterization of a new bleeding disorder. Blood 1982 60:790 PubMed

6. Muszbek L,Laposata M Glycoprotein Ib and glycoprotein IX in human platelets are acylated with palmitic acid through thioester linkages. J Biol Chem 1989 264:9716 PubMed

7. Nurden AT,Dupuis D,Kunicki TJ,Caen JP Analysis of the glycoprotein and protein composition of Bernard-Soulier platelets by single and two-dimensional sodium dodecyl sulfate- polyacrylamide gel electrophoresis. J Clin Invest 1981 67:1431 PubMed

8. Schick PK,Walker J The acylation of megakaryocyte proteins: glycoprotein IX is primarily myristoylated while glycoprotein Ib is palmitoylated. Blood 1996 87:1377 PubMed

9. Weiss HJ,Meyer D,Rabinowitz R,Pietu G,Girma JP,Vicic WJ,Rogers J Pseudo-von Willebrand's disease. An intrinsic platelet defect with aggregation by unmodified human factor VIII/von Willebrand factor and enhanced adsorption of its high-molecular-weight multimers. N Engl J Med 1982 306:326 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov