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PROW: CDw131
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PROW and IWHLDA present the GUIDE on:
CDw131
Author: Atsushi Miyajima
Reviewer: Gerry Krystal
[GUIDE BAR]

ALTERNATE NAMES FOR CDw131  

MAJOR LINKS FOR CDw131  


FUNCTION
BIOCHEMICAL ACTIVITY OF CDw131  

CELLULAR FUNCTION OF CDw131  

DISEASE RELEVANCE OF CDw131 AND FUNCTION OF CDw131 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CDw131  

MOLECULAR STRUCTURE OF CDw131  

MOLECULAR MASS OF CDw131  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Myeloid cells 120-140 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CDw131   - No information

POST-TRANSLATIONAL MODIFICATION OF CDw131  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CDw131   - No information

SUBSTRATES FOR CDw131   - No information

ENZYMES WHICH MODIFY CDw131   - No information

LIGANDS FOR CDw131 AND MOLECULES ASSOCIATED WITH CDw131  

MOLECULECOMMENT
CD123 (IL-3R alpha) See note 1
CDw125 (IL-5R alpha) See note 1
CD116 (GMCSF-R alpha See note 1
JAK2 Tyrosine kinase is associated with CDw131 and tyrosine phosphorylates upon stimulation
Shc See note 2
Grb2 See note 2
SHP1** See note 2
SHP2** See note 2
PI3Kinase See note 2
Stat5 See note 2

EXPRESSION
MAIN CELLULAR EXPRESSION OF CDw131  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CDw131  
REAGENTS
CDw131-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
3D7 (C-65)    
S-16 Santa Cruz Biotechnology Cat#sc-457  

SELECTION OF OTHER CDw131-SPECIFIC REFERENCE MAB   - No information


 
SELECTED REFERENCES ON CDw131  

REVIEWS

1. Miyajima A,Mui AL,Ogorochi T,Sakamaki K Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 1993 82:1960 PubMed

PRIMARY CITATIONS

2. Gorman DM,Itoh N,Kitamura T,Schreurs J,Yonehara S,Yahara I,Arai K,Miyajima A Cloning and expression of a gene encoding an interleukin 3 receptor- like protein: identification of another member of the cytokine receptor gene family. Proc Natl Acad Sci U S A 1990 87:5459 PubMed

3. Hara T,Miyajima A Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3). EMBO J 1992 11:1875 PubMed

4. Hayashida K,Kitamura T,Gorman DM,Arai K,Yokota T,Miyajima A Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A 1990 87:9655 PubMed

5. Itoh N,Yonehara S,Schreurs J,Gorman DM,Maruyama K,Ishii A,Yahara I,Arai K,Miyajima A Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science 1990 247:324 PubMed

6. Itoh T,Muto A,Watanabe S,Miyajima A,Yokota T,Arai K Granulocyte-macrophage colony-stimulating factor provokes RAS activation and transcription of c-fos through different modes of signaling. J Biol Chem 1996 271:7587 PubMed

7. Kitamura T,Sato N,Arai K,Miyajima A Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell 1991 66:1165 PubMed

8. Matsuguchi T,Inhorn RC,Carlesso N,Xu G,Druker B,Griffin JD Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM- CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL. EMBO J 1995 14:257 PubMed

9. Nishinakamura R,Nakayama N,Hirabayashi Y,Inoue T,Aud D,McNeil T,Azuma S,Yoshida S,Toyoda Y,Arai K,et al Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor- deficient mice are normal. Immunity 1995 2:211 PubMed

10. Quelle FW,Sato N,Witthuhn BA,Inhorn RC,Eder M,Miyajima A,Griffin JD,Ihle JN JAK2 associates with the beta c chain of the receptor for granulocyte- macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol Cell Biol 1994 14:4335 PubMed

11. Sato N,Caux C,Kitamura T,Watanabe Y,Arai K,Banchereau J,Miyajima A Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells. Blood 1993 82:752 PubMed

12. Sato N,Sakamaki K,Terada N,Arai K,Miyajima A Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO J 1993 12:4181 PubMed

13. Tavernier J,Devos R,Cornelis S,Tuypens T,Van der Heyden J,Fiers W,Plaetinck G A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell 1991 66:1175 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/14/99   mpr@mail.nih.gov