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PROW: CD64
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PROW and IWHLDA present the GUIDE on:
CD64
Authors: Paul Guyre; Wanwen Sun
Reviewer: Jan G. van de Winkel
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ALTERNATE NAMES FOR CD64  

MAJOR LINKS FOR CD64  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD64   - No information

CELLULAR FUNCTION OF CD64  

DISEASE RELEVANCE OF CD64 AND FUNCTION OF CD64 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD64  

MOLECULAR STRUCTURE OF CD64  

MOLECULAR MASS OF CD64  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Monocytes   72 kDa  
U937, HL-60   72 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD64  

POST-TRANSLATIONAL MODIFICATION OF CD64  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD64  
MOLECULECOMMENT
STAT1 IFN[gamma] induces increased transcription of CD64 in PMN via STAT1 and STAT3 binding to the IFN[gamma] response region (GRR)
STAT3 IFN[gamma] induces increased transcription of CD64 in PMN via STAT1 and STAT3 binding to the IFN[gamma] response region (GRR)
unknown Increased expression in monocytes and macrophages by IFN-[gamma] and IL-10
Unkonwn Decreased expression in monocytes and macrophages by IL-4
Unknown Decreased expression in PMN by glucocorticoids

SUBSTRATES FOR CD64   - No information

ENZYMES WHICH MODIFY CD64   - No information

LIGANDS FOR CD64 AND MOLECULES ASSOCIATED WITH CD64  

MOLECULECOMMENT
IgG human Human CD64 binds human IgG3>IgG1>IgG4>>>IgG2
IgG mouse Human CD64 binds murine IgG3>IgG2a>>>IgG1, IgG2b

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD64  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD64  
REAGENTS
CD64-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - No information

SELECTION OF OTHER CD64-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
22 Guyre PM et al. 1989  
32 Anderson CL et al. 1986  
197 Guyre PM et al. 1989  
10.1 Dougherty GJ 1987  

 
SELECTED REFERENCES ON CD64  

REVIEWS

1. Hulett MD,Hogarth PM Molecular basis of Fc receptor function. Adv Immunol 1994 57:1 PubMed

2. Van de Winkel, J.G.J & Capel, P.J.A. [Editors]. Human IgG Fc Receptors. R.G. Landes Company, Austin, TX, USA, 1996.

3. van de Winkel JG,Capel PJ Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol Today 1993 14:215 PubMed

PRIMARY CITATIONS

4. Anderson CL,Guyre PM,Whitin JC,Ryan DH,Looney RJ,Fanger MW Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes. Antibody characterization and induction of superoxide production in a monocyte cell line. J Biol Chem 1986 261:12856 PubMed

5. Dougherty GJ,Selvendran Y,Murdoch S,Palmer DG,Hogg N The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1. Eur J Immunol 1987 17:1453 PubMed

6. Fanger NA,Wardwell K,Shen L,Tedder TF,Guyre PM Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells. J Immunol 1996 157:541 PubMed

7. Olweus J,Terstappen LW,Thompson PA,Lund-Johansen F Expression and function of receptors for stem cell factor and erythropoietin during lineage commitment of human hematopoietic progenitor cells. Blood 1996 88:1594 PubMed

8. van Vugt MJ,Heijnen AF,Capel PJ,Park SY,Ra C,Saito T,Verbeek JS,van de Winkel JG FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo. Blood 1996 87:3593 PubMed

9. van Vugt MJ,van den Herik-Oudijk IE,van de Winkle JG Binding of PE-CY5 conjugates to the human high-affinity receptor for IgG. Blood 1996 88:2358 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov