Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD157
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD157
Authors: Katsuhiko Ishihara; Toshio Hirano
Reviewer: Robert Todd
[GUIDE BAR]

ALTERNATE NAMES FOR CD157  

MAJOR LINKS FOR CD157  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD157  

CELLULAR FUNCTION OF CD157  

DISEASE RELEVANCE OF CD157 AND FUNCTION OF CD157 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD157  

MOLECULAR STRUCTURE OF CD157  

MOLECULAR MASS OF CD157  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Bone marrow stroma 42-45 kDa 42-45 kDa  
Synovial cells 42-45 kDa 42-45 kDa  
Monocytes (by anti-Mo5) 50 kDa 50 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD157   - No information

POST-TRANSLATIONAL MODIFICATION OF CD157   - Four N-glycosylation sites


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD157   - No information

SUBSTRATES FOR CD157  

MOLECULECOMMENT
NAD  
Cyclic ADP-ribose  

ENZYMES WHICH MODIFY CD157   - No information

LIGANDS FOR CD157 AND MOLECULES ASSOCIATED WITH CD157   - No information


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD157  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD157  
REAGENTS
CD157-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
RF3 (E060, N-L118) Kaisho et al. 1994  
BEC7 (E061, N-L117) Okuyama et al. 1996  
Mo5 (M51) Todd et al. 1985  

SELECTION OF OTHER CD157-SPECIFIC REFERENCE MAB   - No information


 
SELECTED REFERENCES ON CD157  

REVIEWS

PRIMARY CITATIONS

1. Dong C, Wang J, Neame P and Cooper MD. The murine BP-3 gene encodes a relative of the CD38/NAD glycohydrolase family. Int. Immunol. 1994 6:1353 PubMed

2. Goldstein SC and Todd RF 3d. Structural and biosynthetic features of the Mo5 human myeloid differentiation antigen. Tissue Antigens 1993 41:214 PubMed

3. Hirata Y, Kimura N, Sato K, Ohsugi Y, Takasawa S, Okamoto H, Ishikawa J, Kaisho T, Ishihara K and Hirano T. ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1. FEBS Lett. 1994 356:244 PubMed

4. Ishihara K, Kobune Y, Okuyama Y, Itoh M, Lee BO, Muraoka O and Hirano T. Stage-specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor. Int. Immunol. 1996 8:1395 PubMed

5. Itoh M, Ishihara K, Tomizawa H, Tanaka H, Kobune Y, Ishikawa J, Kaisho T and Hirano T. Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase. Biochem. Biophys. Res. Commun. 1994 203:1309 PubMed

6. Kaisho T, Ishikawa J, Oritani K, Inazawa J, Tomizawa H, Muraoka O, Ochi T and Hirano T. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proc. Natl. Acad. Sci. U.S.A. 1994 91:5325 PubMed

7. Lee BO, Ishihara K, Denno K, Kobune Y, Itoh M, Muraoka O, Kaisho T, Sasaki T, Ochi T and Hirano T. Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis. Arthritis Rheum. 1996 39:629 PubMed

8. McNagny KM, Bucy RP and Cooper MD. Reticular cells in peripheral lymphoid tissues express the phosphatidylinositol-linked BP-3 antigen. Eur. J. Immunol. 1991 21:509 PubMed

9. McNagny KM, Cazenave PA and Cooper MD. BP-3 alloantigen. A cell surface glycoprotein that marks early B lineage cells and mature myeloid lineage cells in mice. J. Immunol. 1988 141:2551 PubMed

10. Okuyama Y, Ishihara K, Kimura N, Hirata Y, Sato K, Itoh M, Ok LB and Hirano T. Human BST-1 expressed on myeloid cells functions as a receptor molecule. Biochem. Biophys. Res. Commun. 1996 228:838 PubMed

11. Todd RF 3d, Roach JA and Arnaout MA. The modulated expression of Mo5, a human myelomonocytic plasma membrane antigen. Blood 1985 65:964 PubMed

12. Vicari AP, Bean AG and Zlotnik A. A role for BP-3/BST-1 antigen in early T cell development. Int. Immunol. 1996 8:183 PubMed

WWW RESOURCES

Hirano's web page on BST-1


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov