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PROW: CD2
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PROW and IWHLDA present the GUIDE on:
CD2
Author: Kazunori Kato
Reviewer: Ellis L. Reinherz
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD2  

MAJOR LINKS FOR CD2  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD2  

CELLULAR FUNCTION OF CD2  

DISEASE RELEVANCE OF CD2 AND FUNCTION OF CD2 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD2  

MOLECULAR STRUCTURE OF CD2  

MOLECULAR MASS OF CD2  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Lymphocytes (T, NK) 50 50  

POST-TRANSCRIPTIONAL MODIFICATION OF CD2   - No alternative splicing form

POST-TRANSLATIONAL MODIFICATION OF CD2  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD2 Link to additional info in FORUM   - No report

SUBSTRATES FOR CD2   - No information

ENZYMES WHICH MODIFY CD2   - No information

LIGANDS FOR CD2 AND MOLECULES ASSOCIATED WITH CD2  

MOLECULECOMMENT
CD58 (LFA-3) Ligand, binds to CD2 domain1
CD48 (Blast1) Ligand, binds to CD2 domain1
CD59 (HRF20) Ligand, binds to CD2 domain1
CD15 (Lewis-x) Ligand, bind to multimeric CD2
Sulfated carbohydrate Ligand
CD3-zeta, epsilon chain Associates with CD2, Brown MH et al. 1989
CD16-zeta chain Associates with CD2, Vivier E et al. 1991
CD45 Associates with CD2, Schraven B et al. 1990
CD11a/CD18 Associates with CD2, Altin JG et al. 1994

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD2  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD2  
REAGENTS
CD2-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
LT2 Filatov AV et al. 1989  
MEM-65 Horejsi V (not submitted)  
L303 Azuma M et al. 1992  
RPA-2.10 Aversa G et al. 1987  

SELECTION OF OTHER CD2-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
Leu-5b Becton Dickinson  
OKT11 Ortho Diagnostic Inc.  
NU-TER Nichirei Co.  
9.6 JA Hansen  
39C1.5 Coulter Co.  
6F10.3 Coulter Co.  
9-1 K Naito  
L304 M Azuma  

 
SELECTED REFERENCES ON CD2  

REVIEWS

1. Bell GM,Imboden JB CD2 and the regulation of T cell anergy. J Immunol 1995 155:2805 PubMed

2. Bierer BE,Sleckman BP,Ratnofsky SE,Burakoff SJ The biologic roles of CD2, CD4, and CD8 in T-cell activation. Annu Rev Immunol 1989 7:579 PubMed

3. Moingeon P,Chang HC,Sayre PH,Clayton LK,Alcover A,Gardner P,Reinherz EL The structural biology of CD2. Immunol Rev 1989 111:111 PubMed

PRIMARY CITATIONS

4. Arulanandam AR,Moingeon P,Concino MF,Recny MA,Kato K,Yagita H,Koyasu S,Reinherz EL A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice. J Exp Med 1993 177:1439 PubMed

5. Aversa GG,Bishop GA,Suranyi MG,Hall BM RPA-2.10: an anti-CD2 monoclonal antibody that inhibits alloimmune responses and monitors T cell activation. Transplant Proc 1987 19:277 PubMed

6. Azuma M,Cayabyab M,Buck D,Phillips JH,Lanier LL CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J Exp Med 1992 175:353 PubMed

7. Dustin ML,Sanders ME,Shaw S,Springer TA Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. J Exp Med 1987 165:677 PubMed

8. Dustin ML,Sanders ME,Shaw S,Springer TA Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. J Exp Med 1987 165:677 PubMed

9. Filatov AV,Bachurin PS,Markova NA,Surnakova NE A panel of monoclonal antibodies against human lymphocyte antigens. Eksp Onkol 1989 11:28 PubMed

10. Hahn WC,Menu E,Bothwell AL,Sims PJ,Bierer BE Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. Science 1992 256:1805 PubMed

11. Kato K,Koyanagi M,Okada H,Takanashi T,Wong YW,Williams AF,Okumura K,Yagita H CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. J Exp Med 1992 176:1241 PubMed

12. Schraven B,Wild M,Kirchgessner H,Siebert B,Wallich R,Henning S,Samstag Y,Meuer SC Alterations of CD2 association with T cell receptor signaling molecules in 'CD2 unresponsive' human T lymphocytes. Eur J Immunol 1993 23:119 PubMed

13. Warren HS,Altin JG,Waldron JC,Kinnear BF,Parish CR A carbohydrate structure associated with CD15 (Lewis x) on myeloid cells is a novel ligand for human CD2. J Immunol 1996 156:2866 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/14/99   mpr@mail.nih.gov