Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD116
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD116
Author: Atsushi Miyajima
Reviewer: D. C. Linch
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD116  

MAJOR LINKS FOR CD116  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD116   - No information

CELLULAR FUNCTION OF CD116  

DISEASE RELEVANCE OF CD116 AND FUNCTION OF CD116 IN INTACT ANIMAL   - No information


STRUCTURE
MOLECULAR FAMILY FOR CD116  

MOLECULAR STRUCTURE OF CD116  

MOLECULAR MASS OF CD116  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Myeloid 80 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD116  

POST-TRANSLATIONAL MODIFICATION OF CD116   - Glycosylated


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD116   - No information

SUBSTRATES FOR CD116   - No information

ENZYMES WHICH MODIFY CD116   - No information

LIGANDS FOR CD116 AND MOLECULES ASSOCIATED WITH CD116  

MOLECULECOMMENT
GM-CSF CD116 binds GM-CSF with low affinity and binds it with high affinity when it is coexpressed with the common beta subunit CDw131
CDw131 CD116 interacts with the common beta subunit (CDw131) of the GM-CSF, IL-3, and IL-5 receptors

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD116 Link to additional info in FORUM  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD116   - No information


REAGENTS
CD116-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
C-3 (SCO6)    
C-57 (SCO4)    

SELECTION OF OTHER CD116-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
2B7-17-A Nicola et al. 1993  
S-50 Santa Cruz Biotechnology Cat# sc-456  
S-20 Santa Cruz Biotechnology Cat# sc-458  

 
SELECTED REFERENCES ON CD116  

REVIEWS

1. Miyajima A, Mui AL, Ogorochi T and Sakamaki K. Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 1993 82:1960 PubMed

PRIMARY CITATIONS

2. Crosier KE, Wong GG, Mathey-Prevot B, Nathan DG and Sieff CA. A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. Proc. Natl. Acad. Sci. U.S.A. 1991 88:7744 PubMed

3. Gearing DP, King JA, Gough NM and Nicola NA. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J. 1989 8:3667 PubMed

4. Hayashida K, Kitamura T, Gorman DM, Arai K, Yokota T and Miyajima A. Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc. Natl. Acad. Sci. U.S.A. 1990 87:9655 PubMed

5. Heaney ML, Vera JC, Raines MA and Golde DW. Membrane-associated and soluble granulocyte/macrophage-colony-stimulating factor receptor alpha subunits are independently regulated in HL-60 cells. Proc. Natl. Acad. Sci. U.S.A. 1995 92:2365 PubMed

6. Jubinsky PT, Laurie AS, Nathan DG, Yetz-Aldepe J and Sieff CA. Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit. Blood 1994 84:4174 PubMed

7. Kitamura T, Hayashida K, Sakamaki K, Yokota T, Arai K and Miyajima A. Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proc. Natl. Acad. Sci. U.S.A. 1991 88:5082 PubMed

8. Nicola NA, Wycherley K, Boyd AW, Layton JE, Cary D and Metcalf D. Neutralizing and nonneutralizing monoclonal antibodies to the human granulocyte-macrophage colony-stimulating factor receptor alpha-chain. Blood 1993 82:1724 PubMed

9. Park LS, Martin U, Sorensen R, Luhr S, Morrissey PJ, Cosman D and Larsen A. Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex. Proc. Natl. Acad. Sci. U.S.A. 1992 89:4295 PubMed

10. Ronco LV, Silverman SL, Wong SG, Slamon DJ, Park LS and Gasson JC. Identification of conserved amino acids in the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit critical for function. Evidence for formation of a heterodimeric receptor complex prior to ligand binding. J. Biol. Chem. 1994 269:277 PubMed

11. Sakamaki K, Miyajima I, Kitamura T and Miyajima A. Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J. 1992 11:3541 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov