Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD5
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD5
Authors: Francisco Lozano-Soto; María Simarro; Javier Calvo
Reviewer: Jan L. Ceuppens
[GUIDE BAR]

ALTERNATE NAMES FOR CD5  

MAJOR LINKS FOR CD5  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD5  

CELLULAR FUNCTION OF CD5  

DISEASE RELEVANCE OF CD5 AND FUNCTION OF CD5 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD5  

MOLECULAR STRUCTURE OF CD5  

MOLECULAR MASS OF CD5  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Mature lymphocytes 58 kDa 67 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD5  

POST-TRANSLATIONAL MODIFICATION OF CD5  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD5  
MOLECULECOMMENT
Ets Related transcription factors
PKC-inducible transcription factors  
Ras-dependent transcription factors  

SUBSTRATES FOR CD5   - No information

ENZYMES WHICH MODIFY CD5  

MOLECULECOMMENT
p56 lck Induces Tyr-phosphorylation after TCR/CD3 crosslinking
Serine kinase Still uncharacterized

LIGANDS FOR CD5 AND MOLECULES ASSOCIATED WITH CD5  

MOLECULECOMMENT
CD72 (in man and mouse) Constitutive B cell-specific antigen
gp35-37 (only in mouse) Expressed by activated T and B cells
VH framework regions (only in rabbits)  
TCR Associated molecule
CD3 Associated molecule
CD2 Associated molecule
CD4 Associated molecule
CD8 Associated molecule
B cell receptor (BCR) Associated molecule
CD21 Associated molecule
PTP1C Only in thymocytes
ZAP-70 Only in thymocytes
p21 phospho-zeta Only in thymocytes
PI-3 K Only in thymocytes

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD5  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD5  
REAGENTS
CD5-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
HI 211 (6T-003) DC Shen  
HI SM2 (6T-004) DC Shen  
MEM-128 (6T-014) Vaclav Horejsi  
7.8 (6T-080) G Aversa  

SELECTION OF OTHER CD5-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
OKT1 Reinherz  
Leu-1 Warner  
UCHT2 Beverley  
Cris-1 Vilella  
BL1a Brochier  

 
SELECTED REFERENCES ON CD5  

REVIEWS

1. Kipps TJ. The CD5 B cell. Adv. Immunol. 1988 47:117 PubMed

2. Resnick D, Pearson A and Krieger M. The SRCR superfamily: a family reminiscent of the Ig superfamily. Trends Biochem. Sci. 1993 19:5 PubMed

PRIMARY CITATIONS

3. Alberola-Ila J, Places L, Cantrell DA, Vives J and Lozano F. Intracellular events involved in CD5-induced human T cell activation and proliferation. J. Immunol. 1992 148:1287 PubMed

4. Alberola-Ila J, Places L, Lozano F and Vives J. Association of an activation inducible serine kinase activity with CD5. J. Immunol. 1993 151:4423 PubMed

5. Antin JH, Emerson SG, Martin P, Gadol N and Ault KA. Leu-1+ (CD5+) B cells. A major lymphoid subpopulation in human fetal spleen: phenotypic and functional studies. J. Immunol. 1985 136:505 PubMed

6. Bergui L, Tesio L, Schena M, Riva M, Malavasi F, Schulz T, Marchisio PC and Caligaris-Cappio F. CD5 and CD21 molecules are a functional unit in the cell/substrate adhesion of B-chronic lymphocytic leukemia cells. Eur. J. Immunol. 1988 18:89 PubMed

7. Beyers AD, Spruyt LL and Williams AF. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. U.S.A. 1992 89:2945 PubMed

8. Biancone L, Bowen MA, Lim A, Aruffo A, Andres G and Stamenkovic I. Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes. J. Exp. Med. 1996 184:811 PubMed

9. Bierer BE, Burakoff SJ and Smith BR. A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation. Blood 1989 73:1359 PubMed

10. Bikah G, Carey J, Ciallella JR, Tarakhovsky A and Bondada S. CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. Science 1996 274:1906 PubMed

11. Calvo J, Sole J, Simarro M, Vives J and Lozano F. Evolutionarily conserved transcription regulatory elements within the 5'-flanking region of the human CD5 gene. Tissue Antigens 1996 47:257 PubMed

12. Ceuppens JL, Baroja ML: Monoclonal antibodies to the CD5 antigen can provide the necessary second signal for activation of isolated resting T cells by solid-phase bound OKT3. J Immunol 1986 137: 1816 ** PubMed

13. Davies AA, Ley SC and Crumpton MJ. CD5 is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex. Proc. Natl. Acad. Sci. U.S.A. 1992 89:6368 PubMed

14. Dennehy KM, Broszeit R, Garnett D, Durrheim GA, Spruyt LL and Beyers AD. Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5. Eur. J. Immunol. 1997 27:679 PubMed

15. Gary-Gouy H, Lang V, Sarun S, Boumsell L and Bismuth G. In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and p21 phospho-zeta molecules in human CD3+ thymocytes. J. Immunol. 1997 159:3739 PubMed

16. Jones NH, Clabby ML, Dialynas DP, Huang HJ, Herzenberg LA and Strominger JL. Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1. Nature 1986 323:346 PubMed

17. Lankester AC, van Schijndel GM, Cordell JL, van Noesel CJ and van Lier RA. CD5 is associated with the human B cell antigen receptor complex. Eur. J. Immunol. 1994 24:812 PubMed

18. Ledbetter JA, Parsons M, Martin PJ, Hansen JA, Rabinovitch PS and June CH. Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression. J. Immunol. 1986 137:3299 PubMed

19. Nishimura Y, Bierer BE and Burakoff SJ. Expression of CD5 regulates responsiveness to IL-1. J. Immunol. 1988 141:3438 PubMed

20. Raab M, Yamamoto M and Rudd CE. The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck. Mol. Cell. Biol. 1994 14:2862 PubMed

21. Reinherz EL, Kung PC, Goldstein G and Schlossman SF. A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J. Immunol. 1979 123:1312 PubMed

22. Simarro M, Pelassy C, Calvo J, Places L, Aussel C and Lozano F. The cytoplasmic domain of CD5 mediates both TCR/CD3-dependent and -independent diacylglycerol production. J. Immunol. 1997 159:4307 PubMed

23. Tarakhovsky A, Kanner SB, Hombach J, Ledbetter JA, Muller W, Killeen N and Rajewsky K. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 1995 269:535 PubMed

24. Van de Velde H, von Hoegen I, Luo W, Parnes JR and Thielemans K. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. Nature 1991 351:662 PubMed

25. Vandenberghe P and Ceuppens JL. Immobilized anti-CD5 together with prolonged activation of protein kinase C induce interleukin 2-dependent T cell growth: evidence for signal transduction through CD5. Eur. J. Immunol. 1991 21:251 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov