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PROW: CD90
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD90
Authors: Rachael A. Clark; Timothy A. Springer
Reviewer: Peter M. Lansdorp
[GUIDE BAR]

ALTERNATE NAMES FOR CD90  

MAJOR LINKS FOR CD90  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD90   - None

CELLULAR FUNCTION OF CD90  

DISEASE RELEVANCE OF CD90 AND FUNCTION OF CD90 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD90  

MOLECULAR STRUCTURE OF CD90  

MOLECULAR MASS OF CD90  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
DHL4 B cell lymphoma line 25-35 kDa 25-35 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD90   - No information

POST-TRANSLATIONAL MODIFICATION OF CD90  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD90   - None

SUBSTRATES FOR CD90   - None

ENZYMES WHICH MODIFY CD90   - None

LIGANDS FOR CD90 AND MOLECULES ASSOCIATED WITH CD90  

MOLECULECOMMENT
CD45 Associated molecule required for activation of murine lymphocytes via CD90
lck Noncovalently associated cell-signaling molecules
fyn Noncovalently associated cell-signaling molecules
P100 Noncovalently associated cell-signaling molecules

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD90  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD90  
REAGENTS
CD90-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
V45 Rachael A Clark  
F15-42-1-5 Andre J van Agthoven  

SELECTION OF OTHER CD90-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
5E10 Craig W et al. 1993  

 
SELECTED REFERENCES ON CD90  

REVIEWS

1. Cell surface Thy-1 (ed. A. F. Reif and M. Schlesinger). 1989. Marcel Dekker, Inc. New York.

PRIMARY CITATIONS

2. Craig W,Kay R,Cutler RL,Lansdorp PM Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med 1993 177:1331 PubMed

3. Feng H,Zhao WQ,Bernard CC,Ng KT,Sedman G Purified antichick Thy-1 IgG abolishes intermediate and long-term memory. Physiol Behav 1993 53:215 PubMed

4. Mayani H,Lansdorp PM Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood. Blood 1994 83:2410 ** PubMed

5. Nosten-Bertrand M,Errington ML,Murphy KP,Tokugawa Y,Barboni E,Kozlova E,Michalovich D,Morris RG,Silver J,Stewart CL,Bliss TV,Morris RJ Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature 1996 379:826 PubMed

6. Tiveron MC,Barboni E,Pliego Rivero FB,Gormley AM,Seeley PJ,Grosveld F,Morris R Selective inhibition of neurite outgrowth on mature astrocytes by Thy-1 glycoprotein. Nature 1992 355:745 PubMed

7. Tsukamoto AS,Reading C,Carella A,Frassoni F,Gorin C,LaPorte J,Negrin R,Blume K,Cunningham I,Deisseroth A,et al Biological characterization of stem cell present in mobilized peripheral blood of CML patients. Bone Marrow Transplant 1994 14:S25 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov