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PROW: CD25
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PROW and IWHLDA present the GUIDE on:
CD25
Author: Kazuo Sugamura
Reviewer: Takashi Uchiyama
[GUIDE BAR]

ALTERNATE NAMES FOR CD25  

MAJOR LINKS FOR CD25  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD25   - No information

CELLULAR FUNCTION OF CD25   - IL-2 receptor

DISEASE RELEVANCE OF CD25 AND FUNCTION OF CD25 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD25  

MOLECULAR STRUCTURE OF CD25   - Type I transmembrane molecule

MOLECULAR MASS OF CD25  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Lymphocytes 55kDa 55kDa*  

POST-TRANSCRIPTIONAL MODIFICATION OF CD25   - No information

POST-TRANSLATIONAL MODIFICATION OF CD25  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD25  
MOLECULECOMMENT
Stat5 Transcription factor binds an IL-2 responsive element in CD25 promoter
Elf-1 Transcription factor binds an IL-2 responsive element in CD25 promoter
HGG-I(Y) Transcription factor binds an IL-2 responsive element in CD25 promoter
GATA Transcription factor binds an IL-2 responsive element in CD25 promoter
Tax from HTLV-1  

SUBSTRATES FOR CD25   - No information

ENZYMES WHICH MODIFY CD25   - No information

LIGANDS FOR CD25 AND MOLECULES ASSOCIATED WITH CD25  

MOLECULECOMMENT
IL-2 (interleukin-2)  
CD122 (IL-2R beta) High-affinity IL-2 receptor consists of CD25, CD122 and CD132
CD132 (IL-2R gamma) High-affinity IL-2 receptor consists of CD25, CD122 and CD132

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD25  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD25   - No information


REAGENTS
CD25-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
7G7B6 (C-25) David L Nelson, Bethesda  
MEM-145 (C-53) Vaclav Horejsi, Praha  
Wu949 (C-55) Zhiyou Wang, Wuhan  
MEM-181 (N-L024) Vaclav Horejsi, Praha  

SELECTION OF OTHER CD25-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
anti-Tac Takashi Uchiyama, T et al. 1981  
2A3 DL Urdal, DL et al. 1984  
H-31 Y Tanaka, et al. 1985  

 
SELECTED REFERENCES ON CD25  

REVIEWS

1. Sugamura K,Asao H,Kondo M,Tanaka N,Ishii N,Nakamura M,Takeshita T The common gamma-chain for multiple cytokine receptors. Adv Immunol 1995 59:225 PubMed

2. Tanaka Y,Tozawa H,Hayami M,Sugamura K,Hinuma Y Distinct reactivities of four monoclonal antibodies with human interleukin 2 receptor. Microbiol Immunol 1985 29:959 PubMed

3. Taniguchi T,Minami Y The IL-2/IL-2 receptor system: a current overview. Cell 1993 73:5 ** PubMed

4. Uchiyama T,Broder S,Waldmann TA A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J Immunol 1981 126:1393 PubMed

5. Uchiyama T,Nelson DL,Fleisher TA,Waldmann TA A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells. J Immunol 1981 126:1398 PubMed

6. Urdal DL,March CJ,Gillis S,Larsen A,Dower SK Purification and chemical characterization of the receptor for interleukin 2 from activated human T lymphocytes and from a human T- cell lymphoma cell line. Proc Natl Acad Sci U S A 1984 81:6481 PubMed

7. Waldmann TA The interleukin-2 receptor. J Biol Chem 1991 266:2681 ** PubMed

PRIMARY CITATIONS

8. Cosman D,Cerretti DP,Larsen A,Park L,March C,Dower S,Gillis S,Urdal D Cloning, sequence and expression of human interleukin-2 receptor. Nature 1984 312:768 PubMed

9. Leonard WJ,Depper JM,Crabtree GR,Rudikoff S,Pumphrey J,Robb RJ,Kronke M,Svetlik PB,Peffer NJ,Waldmann TA,et al Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 1984 311:626 PubMed

10. Nikaido T,Shimizu A,Ishida N,Sabe H,Teshigawara K,Maeda M,Uchiyama T,Yodoi J,Honjo T Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature 1984 311:631 PubMed

11. Uchiyama T,Broder S,Waldmann TA A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J Immunol 1981 126:1393 ** PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov