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PROW: CD6
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD6
Authors: Dhavalkumar D. Patel; Barton F. Haynes
Reviewer: Jane R. Parnes
[GUIDE BAR]

ALTERNATE NAMES FOR CD6  

MAJOR LINKS FOR CD6  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD6   - No information

CELLULAR FUNCTION OF CD6  

DISEASE RELEVANCE OF CD6 AND FUNCTION OF CD6 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD6  

MOLECULAR STRUCTURE OF CD6  

MOLECULAR MASS OF CD6  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Peripheral Blood T-Cells   105 kDa or 130 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD6  

POST-TRANSLATIONAL MODIFICATION OF CD6  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD6   - No information

SUBSTRATES FOR CD6   - No information

ENZYMES WHICH MODIFY CD6   - No information

LIGANDS FOR CD6 AND MOLECULES ASSOCIATED WITH CD6  

MOLECULECOMMENT
Activated leukocyte cell adhesion molecule (ALCAM) Divalent cation-independent ligand for CD6. ALCAM binds the membrane proximal SRCR domain (domain 3)
gp90 Potential divalent cation-dependent ligand(s) for CD6, currently unidentified
gp40 Potential divalent cation-dependent ligand(s) for CD6, currently unidentified

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD6  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD6   - No information


REAGENTS
CD6-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
161.8 (NL034) Ramon Villela, Barcelona, Spain  

SELECTION OF OTHER CD6-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
M-T605 Pharmingen  
SPV.L.14 Immunotech  

 
SELECTED REFERENCES ON CD6  

REVIEWS

1. Aruffo A, Bowen MA, Patel DD, Haynes BF, Starling GC, Gebe JA and Bajorath J. CD6-ligand interactions: a paradigm for SRCR domain function? Immunol. Today 1997 18:498 PubMed

PRIMARY CITATIONS

2. Aruffo A, Melnick MB, Linsley PS and Seed B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. J. Exp. Med. 1991 174:949 PubMed

3. Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U and et al. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J. Exp. Med. 1995 181:2213 PubMed

4. Bowen MA, Whitney GS, Neubauer M, Starling GC, Palmer D, Zhang J, Nowak NJ, Shows TB and Aruffo A. Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. J. Immunol. 1997 158:1149 PubMed

5. Gangemi RM, Swack JA, Gaviria DM and Romain PL. Anti-T12, an anti-CD6 monoclonal antibody, can activate human T lymphocytes. J. Immunol. 1989 143:2439 PubMed

6. Patel DD, Wee SF, Whichard LP, Bowen MA, Pesando JM, Aruffo A and Haynes BF. Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells. J. Exp. Med. 1995 181:1563 PubMed

7. Patel DD, Wee SF, Whichard LP, Bowen MA, Pesando JM, Aruffo A and Haynes BF. Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells. J. Exp. Med. 1995 181:1563 PubMed

8. Robinson WH, Neuman de Vegvar HE, Prohaska SS, Rhee JW and Parnes JR. Human CD6 possesses a large, alternatively spliced cytoplasmic domain. Eur. J. Immunol. 1995 25:2765 PubMed

9. Starling GC, Whitney GS, Siadak AW, Llewellyn MB, Bowen MA, Farr AG and Aruffo AA. Characterization of mouse CD6 with novel monoclonal antibodies which enhance the allogeneic mixed leukocyte reaction. Eur. J. Immunol. 1996 26:738 PubMed

10. Wee S, Wang WC, Farr AG, Nelson AJ, Patel DD, Haynes BF, Linsley PS and Aruffo A. Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues. Cell. Immunol. 1994 158:353 PubMed

11. Whitney GS, Starling GC, Bowen MA, Modrell B, Siadak AW and Aruffo A. The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site. J. Biol. Chem. 1995 270:18187 PubMed

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Modified 10/14/99   mpr@mail.nih.gov