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PROW: CD71
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD71
Author: James Goding
Reviewer: Ian Trowbridge
[GUIDE BAR]

ALTERNATE NAMES FOR CD71  

MAJOR LINKS FOR CD71  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD71  

CELLULAR FUNCTION OF CD71  

DISEASE RELEVANCE OF CD71 AND FUNCTION OF CD71 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD71  

MOLECULAR STRUCTURE OF CD71  

MOLECULAR MASS OF CD71  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Proliferating cells 190 kDa 95 kDa  
Reticulocytes 190 kDa 95 kDa  
Brain capillary endothelium 190 kDa 95 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD71  

POST-TRANSLATIONAL MODIFICATION OF CD71  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD71  

SUBSTRATES FOR CD71   - No information

ENZYMES WHICH MODIFY CD71   - No information

LIGANDS FOR CD71 AND MOLECULES ASSOCIATED WITH CD71  

MOLECULECOMMENT
Transferrin (ferrotransferrin) Mediates iron transport, see cellular function

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD71  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD71  
REAGENTS
CD71-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
N-L009 Filatov  
N-L025 Horejsi  
N-L086 Henniker  
N-L115 Wang  
N-L130 Hadam  
N-L134 Buck  
N-L135 Buck  

SELECTION OF OTHER CD71-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
B3/25 Trowbridge et al. 1981  
OKT9 Sutherland et al. 1981; Goding and Burns 1981  

 
SELECTED REFERENCES ON CD71  

REVIEWS

1. Hentze MW,Kuhn LC Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A 1996 93:8175 PubMed

2. Trowbridge IS,Collawn JF,Hopkins CR Signal-dependent membrane protein trafficking in the endocytic pathway. Annu Rev Cell Biol 1993 9:129 PubMed

PRIMARY CITATIONS

3. Barclay, A.N., Birkeland, M.L, Brown, M.H., Beyers, B.D., Davis, S.J., Somoza, C., and Williams, A.F. (1993) In The Leucocyte Antigen Facts Book (ed A.N. Barclay et al.), pp 258-259. Academic Press, London (1993).

4. Goding JW,Burns GF Monoclonal antibody OKT-9 recognizes the receptor for transferrin on human acute lymphocytic leukemia cells. J Immunol 1981 127:1256 PubMed

5. Goding JW,Harris AW Subunit structure of cell surface proteins: disulfide bonding in antigen receptors, Ly-2/3 antigens, and transferrin receptors of murine T and B lymphocytes. Proc Natl Acad Sci U S A 1981 78:4530 PubMed

6. Israeli RS,Powell CT,Fair WR,Heston WD Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res 1993 53:227 PubMed

7. Jamroz RC,Gasdaska JR,Bradfield JY,Law JH Transferrin in a cockroach: molecular cloning, characterization, and suppression by juvenile hormone. Proc Natl Acad Sci U S A 1993 90:1320 PubMed

8. Kuhn LC,McClelland A,Ruddle FH Gene transfer, expression, and molecular cloning of the human transferrin receptor gene. Cell 1984 37:95 PubMed

9. Pytowski B,Judge TW,McGraw TE An internalization motif is created in the cytoplasmic domain of the transferrin receptor by substitution of a tyrosine at the first position of a predicted tight turn. J Biol Chem 1995 270:9067 PubMed

10. Ruoslahti E,Pierschbacher MD New perspectives in cell adhesion: RGD and integrins. Science 1987 238:491 PubMed

11. Schneider C,Owen MJ,Banville D,Williams JG Primary structure of human transferrin receptor deduced from the mRNA sequence. Nature 1984 311:675 PubMed

12. Schneider C,Sutherland R,Newman R,Greaves M Structural features of the cell surface receptor for transferrin that is recognized by the monoclonal antibody OKT9. J Biol Chem 1982 257:8516 PubMed

13. Sutherland R,Delia D,Schneider C,Newman R,Kemshead J,Greaves M Ubiquitous cell-surface glycoprotein on tumor cells is proliferation- associated receptor for transferrin. Proc Natl Acad Sci U S A 1981 78:4515 PubMed

14. Trowbridge IS,Omary MB Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin. Proc Natl Acad Sci U S A 1981 78:3039 PubMed

15. van Driel IR,Stearne PA,Grego B,Simpson RJ,Goding JW The receptor for transferrin on murine myeloma cells: one-step purification based on its physiology, and partial amino acid sequence. J Immunol 1984 133:3220 PubMed

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Modified 10/14/99   mpr@mail.nih.gov