Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD66b
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD66b
Authors: Keith Skubitz; Fritz Grunert; Peter Jantscheff; Motomu Kuroki; Amy Skubitz
Reviewer:
Diverse coauthors in lieu of reviewer
[GUIDE BAR]

ALTERNATE NAMES FOR CD66b  

MAJOR LINKS FOR CD66b  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD66b   - Unclear, see ligands

CELLULAR FUNCTION OF CD66b  

DISEASE RELEVANCE OF CD66b AND FUNCTION OF CD66b IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD66b  

MOLECULAR STRUCTURE OF CD66b  

MOLECULAR MASS OF CD66b  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Granulocytes   95-100 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD66b  

POST-TRANSLATIONAL MODIFICATION OF CD66b  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD66b   - No information

SUBSTRATES FOR CD66b   - No information

ENZYMES WHICH MODIFY CD66b   - No information

LIGANDS FOR CD66b AND MOLECULES ASSOCIATED WITH CD66b  

MOLECULECOMMENT
CD66c CD66b binds the protein core of CD66c not the carbohydrate
src family kinases Some src family kinases associate with CD66b in neutrophils

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD66b   - Granulocytes


 
AUTHOR'S ADDITIONAL INSIGHTS ON CD66b  
REAGENTS
CD66b-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - See reference mAb

SELECTION OF OTHER CD66b-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
80H3 Andre T. van Agthoven, Immunotech SA, 132 Avenue de Lattre de Tessigney  
BD177-13276 Marseille, Cedex 9, France  
BIRMA 17C McDonald, no address  
G10F5 John S. Thompson, University of Kentucky  
B13.9. van der Schoot, Central Laboratory of the Netherlands Red Cross, Amsterdam, The Netherlands  

 
SELECTED REFERENCES ON CD66b  

REVIEWS

PRIMARY CITATIONS

1. Buchegger F,Schreyer M,Carrel S,Mach JP Monoclonal antibodies identify a CEA crossreacting antigen of 95 kD Int J Cancer 1984 33:643 PubMed

2. Arakawa F,Kuroki M,Misumi Y,Oikawa S,Nakazato H,Matsuoka Y Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family. Biochem Biophys Res Commun 1990 166:1063 PubMed

3. Berling B,Kolbinger F,Grunert F,Thompson JA,Brombacher F,Buchegger F,von Kleist S,Zimmermann W Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. Cancer Res 1990 50:6534 PubMed

4. Oikawa S,Inuzuka C,Kuroki M,Arakawa F,Matsuoka Y,Kosaki G,Nakazato H A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. J Biol Chem 1991 266:7995 PubMed

5. Lund-Johansen F,Olweus J,Symington FW,Arli A,Thompson JS,Vilella R,Skubitz K,Horejsi V Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens. Eur J Immunol 1993 23:2782 PubMed

6. Kuijpers TW,van der Schoot CE,Hoogerwerf M,Roos D Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation. J Immunol 1993 151:4934 PubMed

7. Skubitz KM,Campbell KD,Ahmed K,Skubitz AP CD66 family members are associated with tyrosine kinase activity in human neutrophils. J Immunol 1995 155:5382 PubMed

8. Skubitz KM,Campbell KD,Skubitz AP CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. J Leukoc Biol 1996 60:106 PubMed

9. Thompson JA,Grunert F,Zimmermann W Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 1991 5:344 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov