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PROW: CD63
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD63
Authors: Masja de Haas; David O. Azorsa
Reviewer: Martin E. Hemler
[GUIDE BAR]

ALTERNATE NAMES FOR CD63  

MAJOR LINKS FOR CD63  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD63   - No information

CELLULAR FUNCTION OF CD63  

DISEASE RELEVANCE OF CD63 AND FUNCTION OF CD63 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD63  

MOLECULAR STRUCTURE OF CD63  

MOLECULAR MASS OF CD63  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
All 40-60 kDa**    

POST-TRANSCRIPTIONAL MODIFICATION OF CD63   - Unknown**

POST-TRANSLATIONAL MODIFICATION OF CD63  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD63  

SUBSTRATES FOR CD63   - No information**

ENZYMES WHICH MODIFY CD63   - No information**

LIGANDS FOR CD63 AND MOLECULES ASSOCIATED WITH CD63  

MOLECULECOMMENT
VLA-3 (CD29/Cd49c) CD63 has been shown to associate with VLA-3 (CD29/Cd49c) by co-precipitation (Berditchevski et al. 1995)
VLA-6 (CD29/CD49f) CD63 has been shown to associate with VLA-6 (CD29/CD49f) by co-precipitation (Berditchevski et al. 1995)
CD9 Formation of complexes involving CD63 and the TM4SF protein CD9 have also been identified by co-precipitation (Berditchevski et al. 1996; Radford et al. 1996)**
CD81 Formation of complexes involving CD63 and the TM4SF protein CD81 have also been identified by co-precipitation (Berditchevski et al. 1996; Radford et al. 1996)**
PI 4-kinase CD63 is also associated with PI 4-kinase (Berditchevski et al. 1997)**

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD63  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD63  
REAGENTS
CD63-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
TEA 3/18 Sanchez-Madrid, Madrid  
LP9 Partridge, Sheffield  

SELECTION OF OTHER CD63-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
CLB-gran/12 CLB, Amsterdam  
RUU-Sp2.28 Nieuwenhuis, Utrecht  

 
SELECTED REFERENCES ON CD63  

REVIEWS

PRIMARY CITATIONS

1. Berditchevski F, Bazzoni G and Hemler ME. Specific association of CD63 with the VLA-3 and VLA-6 integrins. J. Biol. Chem. 1995 270:17784 PubMed

2. Berditchevski F, Tolias KF, Wong K, Carpenter CL and Hemler ME. A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J. Biol. Chem. 1997 272:2595 ** PubMed

3. Berditchevski F, Zutter MM and Hemler ME. Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Mol. Biol. Cell 1996 7:193 PubMed

4. Hotta H, Miyamoto H, Hara I, Takahashi N and Homma M. Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences. Biochem. Biophys. Res. Commun. 1992 185:436 PubMed

5. Kitani S, Berenstein E, Mergenhagen S, Tempst P and Siraganian RP. A cell surface glycoprotein of rat basophilic leukemia cells close to the high affinity IgE receptor (Fc epsilon RI). Similarity to human melanoma differentiation antigen ME491. J. Biol. Chem. 1991 266:1903 ** PubMed

6. Metzelaar MJ, Wijngaard PL, Peters PJ, Sixma JJ, Nieuwenhuis HK and Clevers HC. CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. J. Biol. Chem. 1991 266:3239 ** PubMed

7. Nieuwenhuis HK, van Oosterhout JJ, Rozemuller E, van Iwaarden F and Sixma JJ. Studies with a monoclonal antibody against activated platelets: evidence that a secreted 53,000-molecular weight lysosome-like granule protein is exposed on the surface of activated platelets in the circulation. Blood 1987 70:838, Stars PubMed

8. Nishikata H, Oliver C, Mergenhagen SE and Siraganian RP. The rat mast cell antigen AD1 (homologue to human CD63 or melanoma antigen ME491) is expressed in other cells in culture. J. Immunol. 1992 149:862 ** PubMed

9. Radford KJ, Mallesch J and Hersey P. Suppression of human melanoma cell growth and metastasis by the melanoma-associated antigen CD63 (ME491). Int. J. Cancer 1995 62:631 ** PubMed

10. Radford KJ, Thorne RF and Hersey P. CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma. Biochem. Biophys. Res. Commun. 1996 222:13 ** PubMed

11. Radford KJ, Thorne RF and Hersey P. Regulation of tumor cell motility and migration by CD63 in a human melanoma cell line. J. Immunol. 1997 158:3353 ** PubMed

12. Sikora LK, Pinto A, Demetrick DJ, Dixon WT, Urbanski SJ, Temple W and Jerry LM. Characterization of a novel neuroglandular antigen (NGA) expressed on abnormal human melanocytes. Int. J. Cancer 1987 39:138 ** PubMed

13. Takahashi N, Hotta H and Homma M. Activation and suppression of a cryptic promoter in the intron of the human melanoma-associated ME491 antigen gene. Jpn. J. Cancer Res. 1991 82:1239 PubMed

14. Vischer UM and Wagner DD. CD63 is a component of Weibel-Palade bodies of human endothelial cells. Blood 1993 82:1184 ** PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov