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PROW: CD73
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PROW and IWHLDA present the GUIDE on:
CD73
Authors: Jacqueline L. Cordell; Laura Airas
Reviewer:
Reviewer became coauthor
[GUIDE BAR]

ALTERNATE NAMES FOR CD73  

MAJOR LINKS FOR CD73  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD73  

CELLULAR FUNCTION OF CD73  

DISEASE RELEVANCE OF CD73 AND FUNCTION OF CD73 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD73  

MOLECULAR STRUCTURE OF CD73  

MOLECULAR MASS OF CD73  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Myeloma cell line U266 69 kDa   Thompson et al. 1990*
Freshly isolated peripheral blood lymphocytes 70 kDa   Airas et al. 1997
Cultured endothelial cells 70 kDa   Airas et al. 1993
Human placenta 72 kDa   Thompson et al. 1990*

POST-TRANSCRIPTIONAL MODIFICATION OF CD73   - No information

POST-TRANSLATIONAL MODIFICATION OF CD73  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD73   - No information

SUBSTRATES FOR CD73  

MOLECULECOMMENT
AMP CD73 (ecto-5'-nucleotidase) hydrolyses extracellular adenosine monophosphate (AMP) into adenosine*

ENZYMES WHICH MODIFY CD73   - No information

LIGANDS FOR CD73 AND MOLECULES ASSOCIATED WITH CD73   - No information


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD73  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD73  
REAGENTS
CD73-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - None

SELECTION OF OTHER CD73-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
AD2 Gwin/Cooper Birmingham, Alabama, USA  
1E9 Thompson et al. 1990*  
7G2 Thompson et al. 1990*  
4G4 Airas et al. 1993, 1995*  

 
SELECTED REFERENCES ON CD73  

REVIEWS

Zimmermann H 5'-Nucleotidase: molecular structure and functional aspects. Biochem J 1992 285:345 ** PubMed

PRIMARY CITATIONS

1. Thomson LF,Ruedi JM,Glass A,Moldenhauer G,Moller P,Low MG,Klemens MR,Massaia M,Lucas AH Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73). Tissue Antigens 1990 35:9 PubMed

2. Airas L,Salmi M,Jalkanen S Lymphocyte-vascular adhesion protein-2 is a novel 70-kDa molecule involved in lymphocyte adhesion to vascular endothelium. J Immunol 1993 151:4228 PubMed

3. Thompson LF,Ruedi JM,O'Connor RD,Bastian JF Ecto-5'-nucleotidase expression during human B cell development. An explanation for the heterogeneity in B lymphocyte ecto-5'-nucleotidase activity in patients with hypogammaglobulinemia. J Immunol 1986 137:2496 * PubMed

4. Salazar-Gonzalez JF,Moody DJ,Giorgi JV,Martinez-Maza O,Mitsuyasu RT,Fahey JL Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity. J Immunol 1985 135:1778 PubMed

5. Barcos, M., Pollard, C., Thompson, L. F., Stoll, H., and Evans, R. L. Leukemia and Lymphoma 6, 503-512(1992).

6. Thompson LF Ecto-5'-nucleotidase can provide the total purine requirements of mitogen-stimulated human T cells and rapidly dividing human B lymphoblastoid cells. J Immunol 1985 134:3794 PubMed

7. Thompson LF,Ruedi JM,Glass A,Low MG,Lucas AH Antibodies to 5'-nucleotidase (CD73), a glycosyl-phosphatidylinositol- anchored protein, cause human peripheral blood T cells to proliferate. J Immunol 1989 143:1815 PubMed

8. Gutensohn W,Resta R,Misumi Y,Ikehara Y,Thompson LF Ecto-5'-nucleotidase activity is not required for T cell activation through CD73. Cell Immunol 1995 161:213 PubMed

9. Airas L,Hellman J,Salmi M,Bono P,Puurunen T,Smith DJ,Jalkanen S CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73. J Exp Med 1995 182:1603 PubMed

10. Airas L,Jalkanen S CD73 mediates adhesion of B cells to follicular dendritic cells. Blood 1996 88:1755 PubMed

11. Airas L,Niemela J,Salmi M,Puurunen T,Smith DJ,Jalkanen S Differential regulation and function of CD73, a glycosyl- phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells. J Cell Biol 1997 136:421 ** PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov