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PROW: CD82
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PROW and IWHLDA present the GUIDE on:
CD82
Author: Helene Conjeaud
Reviewer: Osamu Yoshie
[GUIDE BAR]

ALTERNATE NAMES FOR CD82  

MAJOR LINKS FOR CD82  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD82   - No information

CELLULAR FUNCTION OF CD82  

DISEASE RELEVANCE OF CD82 AND FUNCTION OF CD82 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD82  

MOLECULAR STRUCTURE OF CD82  

MOLECULAR MASS OF CD82  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Varied cell types 45-90 kDa Depending on cell type and state of cell activation*  

POST-TRANSCRIPTIONAL MODIFICATION OF CD82   - No information

POST-TRANSLATIONAL MODIFICATION OF CD82  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD82   - No information

SUBSTRATES FOR CD82   - No information

ENZYMES WHICH MODIFY CD82   - No information

LIGANDS FOR CD82 AND MOLECULES ASSOCIATED WITH CD82  

MOLECULECOMMENT
Other tetraspan molecules Ref 7,8,13
MHC-I Ref 14,15
MHC-II Ref 7,13,15,
Beta1 integrins Ref 8,13
CD4 Ref 5,9. The only p56lck-free CD4 is ref9
CD8 Ref 5

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD82  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD82   - No information


REAGENTS
CD82-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
gC11 (CD82.1 Lebel-Binay S. et al. 1994. Cell. Immunol. 154:468-483  
50F11 (CD82.2) Shaw S and Hallam J NIH, Bethesda  

SELECTION OF OTHER CD82-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
IA4 Ref 2  
4F9 Ref 6  
C33 Ref 3  

 
SELECTED REFERENCES ON CD82  

REVIEWS

Wright MD,Tomlinson MG The ins and outs of the transmembrane 4 superfamily. Immunol Today 1994 15:588 ** PubMed

Hemler ME,Mannion BA,Berditchevski F Association of TM4SF proteins with integrins: relevance to cancer. Biochim Biophys Acta 1996 1287:67 ** PubMed

PRIMARY CITATIONS

1. Gaugitsch HW,Hofer E,Huber NE,Schnabl E,Baumruker T A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23. Eur J Immunol 1991 21:377 PubMed

2. Gil ML,Vita N,Lebel-Binay S,Miloux B,Chalon P,Kaghad M,Marchiol-Fournigault C,Conjeaud H,Caput D,Ferrara P,et al A member of the tetra spans transmembrane protein superfamily is recognized by a monoclonal antibody raised against an HLA class I- deficient, lymphokine-activated killer-susceptible, B lymphocyte line. Cloning and preliminary functional studies. J Immunol 1992 148:2826 PubMed

3. Fukudome K,Furuse M,Imai T,Nishimura M,Takagi S,Hinuma Y,Yoshie O Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)- induced syncytium formation: altered glycosylation of C33 antigen in J Virol 1992 66:1394 ** PubMed

4. Imai T,Fukudome K,Takagi S,Nagira M,Furuse M,Fukuhara N,Nishimura M,Hinuma Y,Yoshie O C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. J Immunol 1992 149:2879 ** PubMed

5. Imai T,Yoshie O C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells. J Immunol 1993 151:6470 ** PubMed

6. Nojima Y,Hirose T,Tachibana K,Tanaka T,Shi L,Doshen J,Freeman GJ,Schlossman SF,Morimoto C The 4F9 antigen is a member of the tetra spans transmembrane protein family and functions as an accessory molecule in T cell activation and adhesion. Cell Immunol 1993 152:249 ** PubMed

7. Angelisova P,Hilgert I,Horejsi V Association of four antigens of the tetraspans family (CD37, CD53, TAPA- 1, and R2/C33) with MHC class II glycoproteins. Immunogenetics 1994 39:249 ** PubMed

8. Mannion BA,Berditchevski F,Kraeft SK,Chen LB,Hemler ME Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). J Immunol 1996 157:2039 ** PubMed

9. Imai T,Kakizaki M,Nishimura M,Yoshie O Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. J Immunol 1995 155:1229 PubMed

10. Lebel-Binay S,Lagaudriere C,Fradelizi D,Conjeaud H CD82, tetra-span-transmembrane protein, is a regulated transducing molecule on U937 monocytic cell line. J Leukoc Biol 1995 57:956 PubMed

11. Lebel-Binay S,Lagaudriere C,Fradelizi D,Conjeaud H CD82, member of the tetra-span-transmembrane protein family, is a costimulatory protein for T cell activation. J Immunol 1995 155:101 PubMed

12. Dong JT,Lamb PW,Rinker-Schaeffer CW,Vukanovic J,Ichikawa T,Isaacs JT,Barrett JC KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 1995 268:884 PubMed

13. Rubinstein E,Le Naour F,Lagaudriere-Gesbert C,Billard M,Conjeaud H,Boucheix C CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins. Eur J Immunol 1996 26:2657 PubMed

14. Lagaudriere-Gesbert C,Lebel-Binay S,Wiertz E,Ploegh HL,Fradelizi D,Conjeaud H The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes. J Immunol 1997 158:2790 PubMed

15. Szollosi J,Horejsi V,Bene L,Angelisova P,Damjanovich S Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. J Immunol 1996 157:2939 PubMed

16. Lebel-Binay S,Gil ML,Lagaudriere C,Miloux B,Marchiol-Fournigault C,Quillet-Mary A,Lopez M,Fradelizi D,Conjeaud H Further characterization of CD82/IA4 antigen (type III surface protein): an activation/differentiation marker of mononuclear cells. Cell Immunol 1994 154:468 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/14/99   mpr@mail.nih.gov