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PROW: CD47
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PROW and IWHLDA present the GUIDE on:
CD47
Authors: Fang F. Yuan; Anne Fletcher
Reviewer: David J. Anstee
[GUIDE BAR]

ALTERNATE NAMES FOR CD47  

MAJOR LINKS FOR CD47  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD47   - No information

CELLULAR FUNCTION OF CD47  

DISEASE RELEVANCE OF CD47 AND FUNCTION OF CD47 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD47  

MOLECULAR STRUCTURE OF CD47  

MOLECULAR MASS OF CD47  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Erythrocytes 45-60 kDa 50-55 kDa  
Platelets 47-55 kDa ~50 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD47  

POST-TRANSLATIONAL MODIFICATION OF CD47  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD47   - No information

SUBSTRATES FOR CD47   - No information

ENZYMES WHICH MODIFY CD47   - No information

LIGANDS FOR CD47 AND MOLECULES ASSOCIATED WITH CD47  

MOLECULECOMMENT
integrin [beta]3(CD61) dependent ligand CD47 is physically and functionally associated with Integrin [beta]3(CD61) dependent ligand*
thrombospondin  

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD47  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD47  
REAGENTS
CD47-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
1/7 (A017) A Fletcher (Sydney)  
MEM122 (A051) V Horejsi (Praha)  
1/1A4 (NL-119) W Knapp and WF Pickl (Vienna)  

SELECTION OF OTHER CD47-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
BRIC 126 6th HLDA reference mAb  
CIKM1 6th HLDA reference mAb  
B6H12 E Brown et al, 1990  

 
SELECTED REFERENCES ON CD47  

REVIEWS

1. Anstee, D. J. and Spring, F. A. In Leucocyte Typing V (ed. Schlossan et al.), pp. 233-4. Oxford University Press. Oxford (1995).

PRIMARY CITATIONS

2. Brown E,Hooper L,Ho T,Gresham H Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins. J Cell Biol 1990 111:2785 PubMed

3. Campbell IG,Freemont PS,Foulkes W,Trowsdale J An ovarian tumor marker with homology to vaccinia virus contains an IgV- like region and multiple transmembrane domains. Cancer Res 1992 52:5416 PubMed

4. Gao AG,Lindberg FP,Finn MB,Blystone SD,Brown EJ,Frazier WA Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J Biol Chem 1996 271:21 PubMed

5. Lindberg FP,Bullard DC,Caver TE,Gresham HD,Beaudet AL,Brown EJ Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science 1996 274:795 PubMed

6. Lindberg FP,Lublin DM,Telen MJ,Veile RA,Miller YE,Donis-Keller H,Brown EJ Rh-related antigen CD47 is the signal-transducer integrin-associated protein. J Biol Chem 1994 269:1567 PubMed

7. Mawby WJ,Holmes CH,Anstee DJ,Spring FA,Tanner MJ Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. Biochem J 1994 304:525 PubMed

8. Reinhold MI,Lindberg FP,Plas D,Reynolds S,Peters MG,Brown EJ In vivo expression of alternatively spliced forms of integrin- associated protein (CD47). J Cell Sci 1995 108:3419 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov