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PROW: CD66e
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD66e
Authors: Keith Skubitz; Fritz Grunert; Peter Jantscheff; Motomu Kuroki; Amy Skubitz
Reviewer:
Diverse coauthors in lieu of reviewer
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD66e  

MAJOR LINKS FOR CD66e  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD66e   - Unclear, see ligands

CELLULAR FUNCTION OF CD66e  

DISEASE RELEVANCE OF CD66e AND FUNCTION OF CD66e IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD66e  

MOLECULAR STRUCTURE OF CD66e  

MOLECULAR MASS OF CD66e  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Epithelial cells   180-200 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD66e  

POST-TRANSLATIONAL MODIFICATION OF CD66e  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD66e  
MOLECULECOMMENT
Upstream stimulatory factor (USF)  
Sp1  
Sp1-like factor  

SUBSTRATES FOR CD66e   - No information

ENZYMES WHICH MODIFY CD66e   - No information

LIGANDS FOR CD66e AND MOLECULES ASSOCIATED WITH CD66e Link to additional info in FORUM  

MOLECULECOMMENT
CD66a Binds the protein core of CD66e not the carbohydrate
CD66c Binds the protein core of CD66e not the carbohydrate
CD66e Binds the protein core of CD66e not the carbohydrate
Unknown molecule on bacteria Binds the carbohydrate on CD66e not the protein core

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD66e   - Epithelial cells


 
AUTHOR'S ADDITIONAL INSIGHTS ON CD66e  
REAGENTS
CD66e-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - See reference mAb

SELECTION OF OTHER CD66e-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
T84.66 Dr. Stanley Hefta, The Beckman Research Institute, Duarte, CA  
26/3/13 Fritz Grunert  
26/5/1 Fritz Grunert  
b7.8.5 Abraham Fuks  

 
SELECTED REFERENCES ON CD66e  

REVIEWS

1. Shively JE,Beatty JD CEA-related antigens: molecular biology and clinical significance. Crit Rev Oncol Hematol 1985 2:355 PubMed

PRIMARY CITATIONS

2. Gold, P., and Freedman, S. O. J. Exp. Med.121, 439-62 (1965).

3. Thompson JA,Grunert F,Zimmermann W Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 1991 5:344 PubMed

4. Oikawa S,Nakazato H,Kosaki G Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. Biochem Biophys Res Commun 1987 142:511 PubMed

5. Benchimol S,Fuks A,Jothy S,Beauchemin N,Shirota K,Stanners CP Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell 1989 57:327 PubMed

6. Oikawa S,Inuzuka C,Kuroki M,Matsuoka Y,Kosaki G,Nakazato H Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. Biochem Biophys Res Commun 1989 164:39 PubMed

7. Leusch HG,Hefta SA,Drzeniek Z,Hummel K,Markos-Pusztai Z,Wagener C Escherichia coli of human origin binds to carcinoembryonic antigen (CEA) and non-specific crossreacting antigen (NCA). FEBS Lett 1990 261:405 PubMed

8. Chen CJ,Li LJ,Maruya A,Shively JE In vitro and in vivo footprint analysis of the promoter of carcinoembryonic antigen in colon carcinoma cells: effects of interferon gamma treatment. Cancer Res 1995 55:3873 PubMed

9. Gangopadhyay A,Bajenova O,Kelly TM,Thomas P Carcinoembryonic antigen induces cytokine expression in Kuppfer cells: implications for hepatic metastasis from colorectal cancer. Cancer Res 1996 56:4805 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov