Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD130
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD130
Authors: Tetsuya Taga; Atsushi Kumanogo
Reviewer: Hugues Gascan
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD130  

MAJOR LINKS FOR CD130  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD130   - No biochemical activity known

CELLULAR FUNCTION OF CD130  

DISEASE RELEVANCE OF CD130 AND FUNCTION OF CD130 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD130  

MOLECULAR STRUCTURE OF CD130  

MOLECULAR MASS OF CD130  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Most cell types ~130-140 ~130-140  

POST-TRANSCRIPTIONAL MODIFICATION OF CD130  

POST-TRANSLATIONAL MODIFICATION OF CD130  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD130   - Not known

SUBSTRATES FOR CD130   - CD130 is not an enzyme

ENZYMES WHICH MODIFY CD130  

MOLECULECOMMENT
Jak1 Receptor associated tyrosine kinases**
Jak2 Receptor associated tyrosine kinases**
Tyk2 Receptor associated tyrosine kinases**

LIGANDS FOR CD130 AND MOLECULES ASSOCIATED WITH CD130  

MOLECULECOMMENT
Oncostatin M The only known direct ligand for CD130
IL-6 (interleukin-6) CD126/CD130
IL-11(interleukin-11) IL-11R/CD130
LIF (leukemia inhibitory factor) LIF-R/CD130
CNF (ciliary neurotrophic factor) LIF-R/CD130
Cardiotrophin-1 LIF-R/CD130
CD130 CD130 forms homodimer in the presence of a complex of interleukin-6 and its receptor or interleukin-11 and its receptor
LIF receptor CD130 forms heterodimer with leukemia inhibitory factor receptor in the presence of leukemia inhibitory factor, oncostatin M, cardioytrophin-1 or a complex of ciliary neurotrophic factor and its receptor
Oncostatin M receptor beta CD130 associates with oncostatin M receptor beta to generate a receptor complex that specifically interacts with oncostatin M**

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD130  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD130   - No information


REAGENTS
CD130-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
B-K5 (C-008) Clement & Wijdenes  
B-L9 (C-010) Clement & Wijdenes  
B-N4 (C-011) Clement & Wijdenes  
B-N9 (C-012) Clement & Wijdenes  
B-R9 (C-013) Clement & Wijdenes  
B-S1 (C-014) Clement & Wijdenes  
B-T6 (C-015) Clement & Wijdenes  
B-T12 (C-016) Clement & Wijdenes  
B-T2 (C-017) Clement & Wijdenes  
B-T9 (C-018) Clement & Wijdenes  
B-P8 (C-019) Clement & Wijdenes  
B-P4 (C-020) Clement & Wijdenes  
B-S12 (C-021) Clement & Wijdenes  
B-R3 (C-022) Clement & Wijdenes  
B-R12 (C-023) Clement & Wijdenes  
B-S8 (C-024) Clement & Wijdenes  
A2 (C-033) Brochier  
B1 (C-034) Brochier  
C2 (C-035) Brochier  
E1 (C-037) Brochier  
F2 (C-038) Brochier  
G1 (C-039) Brochier  
H1 (C-040) Brochier  
I1 (C-041) Brochier  
J1 (C-042) Brochier  
GPX7 (C-043) Yasukawa  

SELECTION OF OTHER CD130-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
AM64 (C-093) Saito et al., 1993  

 
SELECTED REFERENCES ON CD130 Link to additional info in FORUM  

REVIEWS

1. Taga T,Kishimoto T Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997 15:797 PubMed

PRIMARY CITATIONS

2. Gearing DP,Comeau MR,Friend DJ,Gimpel SD,Thut CJ,McGourty J,Brasher KK,King JA,Gillis S,Mosley B,et al The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science 1992 255:1434 ** PubMed

3. Hibi M,Murakami M,Saito M,Hirano T,Taga T,Kishimoto T Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990 63:1149 PubMed

4. Ip NY,Nye SH,Boulton TG,Davis S,Taga T,Li Y,Birren SJ,Yasukawa K,Kishimoto T,Anderson DJ,et al CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell 1992 69:1121 ** PubMed

5. Pennica D,Shaw KJ,Swanson TA,Moore MW,Shelton DL,Zioncheck KA,Rosenthal A,Taga T,Paoni NF,Wood WI Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J Biol Chem 1995 270:10915 ** PubMed

6. Stahl N,Boulton TG,Farruggella T,Ip NY,Davis S,Witthuhn BA,Quelle FW,Silvennoinen O,Barbieri G,Pellegrini S,et al Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science 1994 263:92 ** PubMed

7. Stahl N,Farruggella TJ,Boulton TG,Zhong Z,Darnell JE Jr,Yancopoulos GD Choice of STATs and other substrates specified by modular tyrosine- based motifs in cytokine receptors. Science 1995 267:1349 ** PubMed

8. Yoshida K,Taga T,Saito M,Suematsu S,Kumanogoh A,Tanaka T,Fujiwara H,Hirata M,Yamagami T,Nakahata T,Hirabayashi T,Yoneda Y,Tanaka K,Wang WZ,Mori C,Shiota K,Yoshida N,Kishimoto T Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A 1996 93:407 ** PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov