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PROW: CD18
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD18
Author: Nancy Hogg
Reviewer: Timothy A. Springer
[GUIDE BAR]

ALTERNATE NAMES FOR CD18  

MAJOR LINKS FOR CD18  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD18   - No information

CELLULAR FUNCTION OF CD18  

DISEASE RELEVANCE OF CD18 AND FUNCTION OF CD18 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD18  

MOLECULAR STRUCTURE OF CD18  

MOLECULAR MASS OF CD18  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Leukocytes 90 kDa 95 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD18   - No information

POST-TRANSLATIONAL MODIFICATION OF CD18   - No information


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD18   - No information

SUBSTRATES FOR CD18   - No information

ENZYMES WHICH MODIFY CD18   - No information

LIGANDS FOR CD18 AND MOLECULES ASSOCIATED WITH CD18  


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD18   - Expressed by all leukocytes


 
AUTHOR'S ADDITIONAL INSIGHTS ON CD18   - No information


REAGENTS
CD18-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
7E4 A van Agthoven  
MEM-148 V Horejsi  
AZN-L18 Y van Kooyk  
AZN-L27 Y van Kooyk  
BU86 (4F1) DL Hardie  
BU87 DL Hardie  

SELECTION OF OTHER CD18-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
CLB-LFA-1 R van Lier  
MHM-23 A McMichael  
TS1/18 ATCC/TA Springer  

 
SELECTED REFERENCES ON CD18  

REVIEWS

1. Anderson DC,Springer TA Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med 1987 38:175 PubMed

2. Springer TA Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994 76:301 PubMed

PRIMARY CITATIONS

3. Kishimoto TK,Hollander N,Roberts TM,Anderson DC,Springer TA Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell 1987 50:193 PubMed

4. Kishimoto TK,O'Connor K,Lee A,Roberts TM,Springer TA Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. Cell 1987 48:681 PubMed

5. Law SK,Gagnon J,Hildreth JE,Wells CE,Willis AC,Wong AJ The primary structure of the beta-subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor. EMBO J 1987 6:915 PubMed

6. Weitzman JB,Wells CE,Wright AH,Clark PA,Law SK The gene organisation of the human beta 2 integrin subunit (CD18). FEBS Lett 1991 294:97 PubMed

7. Wilson RW,Ballantyne CM,Smith CW,Montgomery C,Bradley A,O'Brien WE,Beaudet AL Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol 1993 151:1571 PubMed

WWW RESOURCES

CD18 from NCBI Entrez


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov