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PROW: CD127
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD127
Author: Kazuo Sugamura
Reviewer: Brian M. Foxwell
[GUIDE BAR]

ALTERNATE NAMES FOR CD127  

MAJOR LINKS FOR CD127  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD127   - No information

CELLULAR FUNCTION OF CD127  

DISEASE RELEVANCE OF CD127 AND FUNCTION OF CD127 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD127  

MOLECULAR STRUCTURE OF CD127  

MOLECULAR MASS OF CD127  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
B-cell line 65-75 kDa    
T cells 90 kDa **    

POST-TRANSCRIPTIONAL MODIFICATION OF CD127  

POST-TRANSLATIONAL MODIFICATION OF CD127  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD127   - No information

SUBSTRATES FOR CD127   - No information

ENZYMES WHICH MODIFY CD127  

LIGANDS FOR CD127 AND MOLECULES ASSOCIATED WITH CD127  

MOLECULECOMMENT
Interleukin-7  
CD132 (IL-2R gamma) High-affinity IL-7 receptor consists of CD127 and CD132
fyn  
lyn  
Jak1  
PI3K  
lck **

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD127  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD127  
REAGENTS
CD127-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
R34.34 (C-5) Andre van Agthoven, Marseille  

SELECTION OF OTHER CD127-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
hIL-7R-M20 RJ Armitage, Seattle  

 
SELECTED REFERENCES ON CD127  

REVIEWS

1. Komschlies KL,Grzegorzewski KJ,Wiltrout RH Diverse immunological and hematological effects of interleukin 7: implications for clinical application. J Leukoc Biol 1995 58:623 PubMed

PRIMARY CITATIONS

2. Goodwin RG,Friend D,Ziegler SF,Jerzy R,Falk BA,Gimpel S,Cosman D,Dower SK,March CJ,Namen AE,et al Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 1990 60:941 PubMed

3. Namen AE,Lupton S,Hjerrild K,Wignall J,Mochizuki DY,Schmierer A,Mosley B,March CJ,Urdal D,Gillis S Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 1988 333:571 PubMed

4. Peschon JJ,Morrissey PJ,Grabstein KH,Ramsdell FJ,Maraskovsky E,Gliniak BC,Park LS,Ziegler SF,Williams DE,Ware CB,et al Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994 180:1955 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov