Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD44
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD44
Authors: Hua-Xin Liao; Dhavalkumar D. Patel
Reviewer: Paul W. Kincade
[GUIDE BAR]

ALTERNATE NAMES FOR CD44  

MAJOR LINKS FOR CD44  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD44  

CELLULAR FUNCTION OF CD44  

DISEASE RELEVANCE OF CD44 AND FUNCTION OF CD44 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD44  

MOLECULAR STRUCTURE OF CD44  

MOLECULAR MASS OF CD44  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Lymphocyte 85 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD44  

POST-TRANSLATIONAL MODIFICATION OF CD44  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD44   - No information

SUBSTRATES FOR CD44   - No information

ENZYMES WHICH MODIFY CD44  

MOLECULECOMMENT
Protein kinase C  

LIGANDS FOR CD44 AND MOLECULES ASSOCIATED WITH CD44  

MOLECULECOMMENT
Hyaluronan Extracellular ligand
MIP1[beta] Potential ligand via the proteoglycan chain
Osteopontin  
Ankyrin Intercellular association
Fibronectin  

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD44  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD44  
REAGENTS
CD44-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
5F12 Barton F Haynes, Durham, NC, USA  
BJ18 Laurence Boumsell  
BD7 Laurence Boumsell  
B-F24 Desroches C Vermot  
B-G15 Desroches C Vermot  
B-K12 Desroches C Vermot  
B-N5 Desroches C Vermot  
B-R8 Desroches C Vermot  
G44-26 Zhang Chen  
L9 Kikuchi  

SELECTION OF OTHER CD44-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
A3D8 Barton F Haynes, Durham, NC, USA  

 
SELECTED REFERENCES ON CD44  

REVIEWS

1. Haynes BF,Liao HX,Patton KL The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms. Cancer Cells 1991 3:347 PubMed

2. Lesley J,Hyman R,Kincade PW CD44 and its interaction with extracellular matrix. Adv Immunol 1993 54:271 PubMed

PRIMARY CITATIONS

3. Aruffo A,Stamenkovic I,Melnick M,Underhill CB,Seed B CD44 is the principal cell surface receptor for hyaluronate. Cell 1990 61:1303 PubMed

4. Bartolazzi A,Nocks A,Aruffo A,Spring F,Stamenkovic I Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. J Cell Biol 1996 132:1199 PubMed

5. Goldstein LA,Zhou DF,Picker LJ,Minty CN,Bargatze RF,Ding JF,Butcher EC A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell 1989 56:1063 PubMed

6. Kalomiris EL,Bourguignon LY Lymphoma protein kinase C is associated with the transmembrane glycoprotein, GP85, and may function in GP85-ankyrin binding. J Biol Chem 1989 264:8113 PubMed

7. Katoh S,Zheng Z,Oritani K,Shimozato T,Kincade PW Glycosylation of CD44 negatively regulates its recognition of hyaluronan. J Exp Med 1995 182:419 ** PubMed

8. Kohda D,Morton CJ,Parkar AA,Hatanaka H,Inagaki FM,Campbell ID,Day AJ Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration. Cell 1996 86:767 PubMed

9. Mikecz K,Brennan FR,Kim JH,Glant TT Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat Med 1995 1:558 PubMed

10. Miyake K,Underhill CB,Lesley J,Kincade PW Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 1990 172:69 ** PubMed

11. Screaton GR,Bell MV,Jackson DG,Cornelis FB,Gerth U,Bell JI Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci U S A 1992 89:12160 PubMed

12. Stamenkovic I,Amiot M,Pesando JM,Seed B A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell 1989 56:1057 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov