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PROW: CD36
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PROW and IWHLDA present the GUIDE on:
CD36
Authors: Laurence M. Howard; J. L. McGregor
Reviewer: Laurent Daviet
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD36  

MAJOR LINKS FOR CD36  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD36  

CELLULAR FUNCTION OF CD36  

DISEASE RELEVANCE OF CD36 AND FUNCTION OF CD36 IN INTACT ANIMAL Link to additional info in FORUM  


STRUCTURE
MOLECULAR FAMILY FOR CD36  

MOLECULAR STRUCTURE OF CD36  

MOLECULAR MASS OF CD36  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Platelets 88 kDa / 113 kDa    
Fetal Erythrocytes 78 kDa    
Mammary epithelial Cells 85 kDa    
Erythroleukeimic 88 kDa, 85 kDa, 57 kDa    
HeLa 85 (160) kDa 85 kDa  
Dermal Microvascular endothelial cells 80-90 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CD36  

POST-TRANSLATIONAL MODIFICATION OF CD36  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD36  
MOLECULECOMMENT
Oct-2 The first gene shown to be regulated by the Oct-2 transcription factor during B cell differentiation
PEBP2 The PEBP2/CBF transcription factors may be important for the constitutive expression of CD36 in monocyte
CBF The PEBP2/CBF transcription factors may be important for the constitutive expression of CD36 in monocyte

SUBSTRATES FOR CD36  

ENZYMES WHICH MODIFY CD36  

LIGANDS FOR CD36 AND MOLECULES ASSOCIATED WITH CD36  

MOLECULECOMMENT
Oxidized low density lipoprotein Ligand
Long chain fatty acids Ligand
Anionic phospholipids Ligand
Collagen types I, IV and V Ligand
Thrombospondin Ligand
Plasmodium falciparum infected erythrocytes Ligand

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD36  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD36  
REAGENTS
CD36-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
185-1G2 Vilella  
131.1 Tandon, Rockville  
131.2 Tandon, Rockville  
131.4 Tandon, Rockville  
131.5 Tandon, Rockville  
131.7 Tandon, Rockville  
NAM28-8C12 Blanchard, Nantes  
AmAK-5 Kehrel, Muenster  

SELECTION OF OTHER CD36-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
CLB-IVC7 CLB, Amsterdam  
Lyp 10.5 McGregor, Lyon  
Lyp 13.10 McGregor, Lyon  

 
SELECTED REFERENCES ON CD36  

REVIEWS

1. Daviet, L. et al. 1996. Platelets 7:117-124.

2. Greenwalt DE,Lipsky RH,Ockenhouse CF,Ikeda H,Tandon NN,Jamieson GA Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine. Blood 1992 80:1105 PubMed

3. Krieger M,Herz J Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem 1994 63:601 PubMed

4. Savill J,Fadok V,Henson P,Haslett C Phagocyte recognition of cells undergoing apoptosis. Immunol Today 1993 14:131 PubMed

PRIMARY CITATIONS

5. Armesilla AL,Vega MA Structural organization of the gene for human CD36 glycoprotein. J Biol Chem 1994 269:18985 PubMed

6. Asch AS,Liu I,Briccetti FM,Barnwell JW,Kwakye-Berko F,Dokun A,Goldberger J,Pernambuco M Analysis of CD36 binding domains: ligand specificity controlled by dephosphorylation of an ectodomain. Science 1993 262:1436 PubMed

7. Endemann G,Stanton LW,Madden KS,Bryant CM,White RT,Protter AA CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem 1993 268:11811 PubMed

8. Huang MM,Bolen JB,Barnwell JW,Shattil SJ,Brugge JS Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci U S A 1991 88:7844 PubMed

9. Konig H,Pfisterer P,Corcoran LM,Wirth T Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2. Genes Dev 1995 9:1598 PubMed

10. Tang Y,Taylor KT,Sobieski DA,Medved ES,Lipsky RH Identification of a human CD36 isoform produced by exon skipping. Conservation of exon organization and pre-mRNA splicing patterns with a CD36 gene family member, CLA-1. J Biol Chem 1994 269:6011 PubMed

11. Yamamoto N,Akamatsu N,Sakuraba H,Yamazaki H,Tanoue K Platelet glycoprotein IV (CD36) deficiency is associated with the absence (type I) or the presence (type II) of glycoprotein IV on monocytes. Blood 1994 83:392 PubMed

WWW RESOURCES


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Modified 10/14/99   mpr@mail.nih.gov