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PROW: CD98
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PROW and IWHLDA present the GUIDE on:
CD98
Authors: Luis Diaz; David Fox
Reviewer: Barton F. Haynes
[GUIDE BAR]

ALTERNATE NAMES FOR CD98  

MAJOR LINKS FOR CD98  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD98  

CELLULAR FUNCTION OF CD98  

DISEASE RELEVANCE OF CD98 AND FUNCTION OF CD98 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD98  

MOLECULAR STRUCTURE OF CD98  

MOLECULAR MASS OF CD98  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Various cells 125 kDa 80 kDa and 45 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD98   - Unknown

POST-TRANSLATIONAL MODIFICATION OF CD98  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD98  
MOLECULECOMMENT
Sp1 four Sp1 binding sites
NF-4FA First intron contains a binding site for the enhancers, NF-4FA and NF-4FB (6,7)
NF-4FB First intron contains a binding site for the enhancers, NF-4FA and NF-4FB (6,7)

SUBSTRATES FOR CD98  

MOLECULECOMMENT
Neutral amino acids (4)
Dibasic amino acids (4)

ENZYMES WHICH MODIFY CD98   - No information

LIGANDS FOR CD98 AND MOLECULES ASSOCIATED WITH CD98  

MOLECULECOMMENT
Actin CD98 is strongly associated with actin

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD98  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD98  
REAGENTS
CD98-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
(NL-17)    
(NL-42)    
(NL-44)    
(NL-77)    
(NL-79)    
(NL-124)    
(NL-147)    
(NL-148)    
(M-40)    
(M-42)    
(A119)    

SELECTION OF OTHER CD98-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
4F2 Ref (1)  
7F8 Ref (3)  

 
SELECTED REFERENCES ON CD98  

REVIEWS

PRIMARY CITATIONS

1. Haynes BF,Hemler ME,Mann DL,Eisenbarth GS,Shelhamer J,Mostowski HS,Thomas CA,Strominger JL,Fauci AS Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. J Immunol 1981 126:1409 PubMed

2. Ohgimoto S,Tabata N,Suga S,Nishio M,Ohta H,Tsurudome M,Komada H,Kawano M,Watanabe N,Ito Y Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160- mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules. J Immunol 1995 155:3585 PubMed

3. Freidman AW,Diaz LA Jr,Moore S,Schaller J,Fox DA The human 4F2 antigen: evidence for cryptic and noncryptic epitopes and for a role of 4F2 in human T lymphocyte activation. Cell Immunol 1994 154:253 PubMed

4. Bertran J,Magagnin S,Werner A,Markovich D,Biber J,Testar X,Zorzano A,Kuhn LC,Palacin M,Murer H Stimulation of system y(+)-like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes. Proc Natl Acad Sci U S A 1992 89:5606 PubMed

5. Lumadue JA,Glick AB,Ruddle FH Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2. Proc Natl Acad Sci U S A 1987 84:9204 PubMed

6. Leiden JM,Yang LH,Morle GD,June CH,Lindsten T,Thompson CB,Karpinski B The 4F2 heavy chain gene: a molecular model of inducible gene expression in human T cells. J Autoimmun 1989 2:67 PubMed

7. Karpinski BA,Yang LH,Cacheris P,Morle GD,Leiden JM The first intron of the 4F2 heavy-chain gene contains a transcriptional enhancer element that binds multiple nuclear proteins. Mol Cell Biol 1989 9:2588 PubMed

8. Boumsell, L, Leucocyte Typing V: White Cell Differentiation Antigens, S.F. Schlossman, et al, Eds. (Oxford, Oxford, 1995), p. 280.

9. Wells RG,Lee WS,Kanai Y,Leiden JM,Hediger MA The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes. J Biol Chem 1992 267:15285 PubMed

10. Palacin M A new family of proteins (rBAT and 4F2hc) involved in cationic and zwitterionic amino acid transport: a tale of two proteins in search of a transport function. J Exp Biol 1994 196:123 PubMed

11. Bron C,Rousseaux M,Spiazzi AL,MacDonald HR Structural homology between the human 4F2 antigen and a murine cell surface glycoprotein associated with lymphocyte activation. J Immunol 1986 137:397 PubMed

12. Lindsten T,June CH,Thompson CB,Leiden JM Regulation of 4F2 heavy-chain gene expression during normal human T- cell activation can be mediated by multiple distinct molecular mechanisms. Mol Cell Biol 1988 8:3820 PubMed

13. Gottesdiener KM,Karpinski BA,Lindsten T,Strominger JL,Jones NH,Thompson CB,Leiden JM Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation. Mol Cell Biol 1988 8:3809 PubMed

14. Parmacek MS,Karpinski BA,Gottesdiener KM,Thompson CB,Leiden JM Structure, expression and regulation of the murine 4F2 heavy chain. Nucleic Acids Res 1989 17:1915 PubMed

15. Francke U,Foellmer BE,Haynes BF Chromosome mapping of human cell surface molecules: monoclonal anti- human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11. Somatic Cell Genet 1983 9:333 PubMed

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Modified 10/14/99   mpr@mail.nih.gov