Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD94
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD94
Author: Miguel Lopez-Botet
Reviewer: Michael J. Robertson
[GUIDE BAR]

ALTERNATE NAMES FOR CD94  

MAJOR LINKS FOR CD94  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD94  

CELLULAR FUNCTION OF CD94  

DISEASE RELEVANCE OF CD94 AND FUNCTION OF CD94 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD94  

MOLECULAR STRUCTURE OF CD94  

MOLECULAR MASS OF CD94  

POST-TRANSCRIPTIONAL MODIFICATION OF CD94   -

POST-TRANSLATIONAL MODIFICATION OF CD94  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD94   -

SUBSTRATES FOR CD94   -

ENZYMES WHICH MODIFY CD94   -

LIGANDS FOR CD94 AND MOLECULES ASSOCIATED WITH CD94  

MOLECULECOMMENT
NKG2-A (kp43) 43kd C-type lectin associated covalently with CD94
p39 39kd C-type lectin associated covalently with CD94

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD94  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD94  
REAGENTS
CD94-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
NKH3 M Robertson  

SELECTION OF OTHER CD94-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
HP-3B1 M Lopez-Botet  
HP-3D9 M Lopez-Botet  
XA185 A Moretta  

 
SELECTED REFERENCES ON CD94  

REVIEWS

1. Lopez-Botet M,Perez-Villar JJ,Carretero M,Rodriguez A,Melero I,Bellon T,Llano M,Navarro F Structure and function of the CD94 C-type lectin receptor complex involved in recognition of HLA class I molecules. Immunol Rev 1997 155:165 PubMed

2. Moretta A,Biassoni R,Bottino C,Pende D,Vitale M,Poggi A,Mingari MC,Moretta L Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol Rev 1997 155:105 PubMed

PRIMARY CITATIONS

3. Aramburu J,Balboa MA,Izquierdo M,Lopez-Botet M A novel functional cell surface dimer (Kp43) expressed by natural killer cells and gamma/delta TCR+ T lymphocytes. II. Modulation of natural killer cytotoxicity by anti-Kp43 monoclonal antibody. J Immunol 1991 147:714 PubMed

4. Brumbaugh KM,Perez-Villar JJ,Dick CJ,Schoon RA,Lopez-Botet M,Leibson PJ Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses. J Immunol 1996 157:2804 PubMed

5. Carretero M,Cantoni C,Bellon T,Bottino C,Biassoni R,Rodriguez A,Perez-Villar JJ,Moretta L,Moretta A,Lopez-Botet M The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules. Eur J Immunol 1997 27:563 PubMed

6. Chang C,Rodriguez A,Carretero M,Lopez-Botet M,Phillips JH,Lanier LL Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. Eur J Immunol 1995 25:2433 PubMed

7. Lazetic S,Chang C,Houchins JP,Lanier LL,Phillips JH Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J Immunol 1996 157:4741 PubMed

8. Lopez-Botet, M. 1995. In Leucocyte Typing V (ed. S.F. Schlossman et al.). Oxford University Press, Oxford, pp. 1437-39.

9. Moretta A,Vitale M,Sivori S,Bottino C,Morelli L,Augugliaro R,Barbaresi M,Pende D,Ciccone E,Lopez-Botet M,et al Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles. J Exp Med 1994 180:545 PubMed

10. Perez-Villar JJ,Carretero M,Navarro F,Melero I,Rodriguez A,Bottino C,Moretta A,Lopez-Botet M Biochemical and serologic evidence for the existence of functionally distinct forms of the CD94 NK cell receptor. J Immunol 1996 157:5367 PubMed

11. Perez-Villar JJ,Melero I,Rodriguez A,Carretero M,Aramburu J,Sivori S,Orengo AM,Moretta A,Lopez-Botet M Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen. J Immunol 1995 154:5779 PubMed

12. Phillips JH,Chang C,Mattson J,Gumperz JE,Parham P,Lanier LL CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. Immunity 1996 5:163 PubMed

13. Sivori S,Vitale M,Bottino C,Marcenaro E,Sanseverino L,Parolini S,Moretta L,Moretta A CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. Eur J Immunol 1996 26:2487 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov