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PROW: CD42c
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PROW and IWHLDA present the GUIDE on:
CD42c
Authors: Masja de Haas; Albert von dem Borne
Reviewer: Kenneth J. Clemetson
[GUIDE BAR]

ALTERNATE NAMES FOR CD42c  

MAJOR LINKS FOR CD42c  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD42c  

CELLULAR FUNCTION OF CD42c  

DISEASE RELEVANCE OF CD42c AND FUNCTION OF CD42c IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD42c  

MOLECULAR STRUCTURE OF CD42c  

MOLECULAR MASS OF CD42c  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Platelets 160 kDa 24 kDa (+145, GPIb alpha)  

POST-TRANSCRIPTIONAL MODIFICATION OF CD42c   - No information

POST-TRANSLATIONAL MODIFICATION OF CD42c  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD42c  
MOLECULECOMMENT
GATA-1  
Ets  

SUBSTRATES FOR CD42c   - No information

ENZYMES WHICH MODIFY CD42c  

MOLECULECOMMENT
cAMP dependent protein kinase  

LIGANDS FOR CD42c AND MOLECULES ASSOCIATED WITH CD42c  

MOLECULECOMMENT
CD42a CD42c is non-covalently linked with CD42a
CD42b CD42c forms a disulfide-linked heterodimer with CD42b
CD42d CD42c is non-covalently linked with CD42d

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD42c  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD42c   - No information


REAGENTS
CD42c-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - None

SELECTION OF OTHER CD42c-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
GI-27 Santoso, Giessen, Germany  

 
SELECTED REFERENCES ON CD42c  

REVIEWS

PRIMARY CITATIONS

1. Clemetson KJ, McGregor JL, James E, Dechavanne M and Luscher EF. Characterization of the platelet membrane glycoprotein abnormalities in Bernard-Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis. J. Clin. Invest. 1982 70:304 PubMed

2. Fox JE, Aggerbeck LP and Berndt MC. Structure of the glycoprotein Ib.IX complex from platelet membranes. J. Biol. Chem. 1988 263:4882 PubMed

3. Kunishima S, Lopez JA, Kobayashi S, Imai N, Kamiya T, Saito H and Naoe T. Missense mutations of the glycoprotein (GP) Ib beta gene impairing the GPIb alpha/beta disulfide linkage in a family with giant platelet disorder. Blood 1997 89:2404 PubMed

4. Lopez JA, Chung DW, Fujikawa K, Hagen FS, Davie EW and Roth GJ. The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence. Proc. Natl. Acad. Sci. U.S.A. 1988 85:2135 PubMed

5. Ludlow LB, Schick BP, Budarf ML, Driscoll DA, Zackai EH, Cohen A and Konkle BA. Identification of a mutation in a GATA binding site of the platelet glycoprotein Ibbeta promoter resulting in the Bernard-Soulier syndrome. J. Biol. Chem. 1996 271:22076 PubMed

6. Muszbek L and Laposata M. Glycoprotein Ib and glycoprotein IX in human platelets are acylated with palmitic acid through thioester linkages. J. Biol. Chem. 1989 264:9716 PubMed

7. Nurden AT, Dupuis D, Kunicki TJ and Caen JP. Analysis of the glycoprotein and protein composition of Bernard-Soulier platelets by single and two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. J. Clin. Invest. 1981 67:1431 PubMed

8. Schick PK and Walker J. The acylation of megakaryocyte proteins: glycoprotein IX is primarily myristoylated while glycoprotein Ib is palmitoylated. Blood 1996 87:1377 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov