Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD152
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD152
Author: Peter S. Linsley
Reviewer: Miyuki Azuma
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD152  

MAJOR LINKS FOR CD152  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD152   - No information

CELLULAR FUNCTION OF CD152  

DISEASE RELEVANCE OF CD152 AND FUNCTION OF CD152 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD152  

MOLECULAR STRUCTURE OF CD152  

MOLECULAR MASS OF CD152  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
COS ~46 kDa ~30 kDa  
Activated peripheral blood (PBL) ~50 kDa ~33 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD152  

POST-TRANSLATIONAL MODIFICATION OF CD152  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD152  
MOLECULECOMMENT
AP-1 See NOTE
CD28re See NOTE
IL-2kappab See NOTE
OCT-1 See NOTE

SUBSTRATES FOR CD152   - No information

ENZYMES WHICH MODIFY CD152   - No information

LIGANDS FOR CD152 AND MOLECULES ASSOCIATED WITH CD152  

MOLECULECOMMENT
CD80 (ligand for CD28) CD152 (CTLA-4) is a high avidity receptor for CD80
CD86 (ligand for CD28) CD152 (CTLA-4) is a high avidity receptor for CD86
phosphatidylinositol 3-kinase (PI 3-kinase) The cytoplasmic region of CD152 (CTLA-4) contains the motif -YVKM- which binds PI 3-kinase
protein tyrosine phosphatase 1D (PTP1D) Association of CD152 (CTLA-4) with PTP1D has been reported

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD152  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD152  
REAGENTS
CD152-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
11D4 Linsley et al. 1992  
10A8 Linsley et al. 1992  
7F8 Linsley et al. 1992  

SELECTION OF OTHER CD152-SPECIFIC REFERENCE MAB Link to additional info in FORUM  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
BN13.1 Wang et al. 1996 This is not a "workshop mAb" but in an abstract submitted to the workshop, this mAb seemed to have similar properties to mAbs 11D4 and 10A8

 
SELECTED REFERENCES ON CD152  

REVIEWS

PRIMARY CITATIONS

1. Allison JP and Krummel MF. The Yin and Yang of T cell costimulation. Science 1995 270:932 PubMed

2. Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG and Golstein P. A new member of the immunoglobulin superfamily--CTLA-4. Nature 1987 328:267 PubMed

3. Harper K, Balzano C, Rouvier E, Mattei MG, Luciani MF and Golstein P. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. J. Immunol. 1991 147:1037 PubMed

4. Krummel MF and Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 1995 182:459 PubMed

5. Leach DR, Krummel MF and Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996 271:1734 PubMed

6. Linsley PS and Golstein P. Lymphocyte activation: T-cell regulation by CTLA-4. Curr. Biol. 1996 6:398 PubMed

7. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK and Ledbetter JA. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 1991 174:561 PubMed

8. Linsley PS. Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation? J. Exp. Med. 1995 182:289 PubMed

9. Perkins D, Wang Z, Donovan C, He H, Mark D, Guan G, Wang Y, Walunas T, Bluestone J, Listman J and et al. Regulation of CTLA-4 expression during T cell activation. J. Immunol. 1996 156:4154 PubMed

10. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA and Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995 3:541 PubMed

11. Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB and Bluestone JA. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994 1:405 PubMed

12. Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H and Mak TW. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995 270:985 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov