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PROW: CD43
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PROW and IWHLDA present the GUIDE on:
CD43
Author: Vaclav Horejsi
Reviewer: Reinhold Schmidt
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ALTERNATE NAMES FOR CD43  

MAJOR LINKS FOR CD43  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD43   - No information

CELLULAR FUNCTION OF CD43  

DISEASE RELEVANCE OF CD43 AND FUNCTION OF CD43 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD43  

MOLECULAR STRUCTURE OF CD43  

MOLECULAR MASS OF CD43  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
T lymphocytes 95-115 kDa 95-115 kDa  
Activ. T lymphocytes 115-135 kDa 115-135 kDa  
Neutrophils 115-135 kDa 115-135** kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD43  

POST-TRANSLATIONAL MODIFICATION OF CD43  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD43  
MOLECULECOMMENT
Sp1 Tissue specific expression is achieved by DNA methylation in the 5'-region of the CD43 gene (Kudo and Fukuda 1995)

SUBSTRATES FOR CD43   - No information

ENZYMES WHICH MODIFY CD43  

MOLECULECOMMENT
Protein kinase C Phosphorylation of the intracellular region after cell activation

LIGANDS FOR CD43 AND MOLECULES ASSOCIATED WITH CD43  

MOLECULECOMMENT
CD54 Single report (Rosenstein T et al. 1991); Somewhat controversial; It remains to be confirmed that this interaction is relevant under physiological conditions

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD43  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD43  
REAGENTS
CD43-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
CBF.78 Georges Delsol, Toulouse  
148.1B6 Ramon Vilella, Barcelona  
148.1C3 Ramon Vilella, Barcelona  
148.3D4 Ramon Vilella, Barcelona  
161.46 Ramon Vilella, Barcelona  
RDP.AD9 Rolf D Petterson, Oslo  
OH.01 Masaaki Higashihara, Tokyo  
HI165 Shen de Cheng, Tianjin  
HI161 Shen de Cheng, Tianjin  
1G10 Ernie Huang, San Diego  

SELECTION OF OTHER CD43-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
G10.2 Joshua Ledbetter, Seattle  
L60 David Buck, Mountain View  
MEM-59 Vaclav Horejsi, Prague  
L10 Eileen Remold O'Donnell, Boston  
10G7 Walter Knapp, Vienna  
BRA7G Branko Chorvath, Bratislava  

 
SELECTED REFERENCES ON CD43  

REVIEWS

PRIMARY CITATIONS

1. Alvarado M,Klassen C,Cerny J,Horejsi V,Schmidt RE MEM-59 monoclonal antibody detects a CD43 epitope involved in lymphocyte activation. Eur J Immunol 1995 25:1051 PubMed

2. Bazil V,Brandt J,Tsukamoto A,Hoffman R Apoptosis of human hematopoietic progenitor cells induced by crosslinking of surface CD43, the major sialoglycoprotein of leukocytes. Blood 1995 86:502 PubMed

3. Cyster JG,Shotton DM,Williams AF The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation. EMBO J 1991 10:893 PubMed

4. Kudo S,Fukuda M Tissue-specific transcriptional regulation of human leukosialin (CD43) gene is achieved by DNA methylation. J Biol Chem 1995 270:13298 PubMed

5. Manjunath N,Johnson RS,Staunton DE,Pasqualini R,Ardman B Targeted disruption of CD43 gene enhances T lymphocyte adhesion. J Immunol 1993 151:1528 PubMed

6. Mentzer SJ,Remold-O'Donnell E,Crimmins MA,Bierer BE,Rosen FS,Burakoff SJ Sialophorin, a surface sialoglycoprotein defective in the Wiskott- Aldrich syndrome, is involved in human T lymphocyte proliferation. J Exp Med 1987 165:1383 PubMed

7. Nong YH,Remold-O'Donnell E,LeBien TW,Remold HG A monoclonal antibody to sialophorin (CD43) induces homotypic adhesion and activation of human monocytes. J Exp Med 1989 170:259 PubMed

8. Pallant A,Eskenazi A,Mattei MG,Fournier RE,Carlsson SR,Fukuda M,Frelinger JG Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proc Natl Acad Sci U S A 1989 86:1328 PubMed

9. Rosenstein Y,Park JK,Hahn WC,Rosen FS,Bierer BE,Burakoff SJ CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. Nature 1991 354:233 PubMed

10. Schmid K,Hediger MA,Brossmer R,Collins JH,Haupt H,Marti T,Offner GD,Schaller J,Takagaki K,Walsh MT,et al Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). Proc Natl Acad Sci U S A 1992 89:663 PubMed

11. Shelley CS,Remold-O'Donnell E,Rosen FS,Whitehead AS Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. Biochem J 1990 270:569 PubMed

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Modified 10/14/99   mpr@mail.nih.gov