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PROW: CD27
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PROW and IWHLDA present the GUIDE on:
CD27
Authors: Tetsuji Kobata; Chikao Morimoto
Reviewer: Rene A. van Lier
[GUIDE BAR]

ALTERNATE NAMES FOR CD27  

MAJOR LINKS FOR CD27  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD27  

CELLULAR FUNCTION OF CD27  

DISEASE RELEVANCE OF CD27 AND FUNCTION OF CD27 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD27  

MOLECULAR STRUCTURE OF CD27  

MOLECULAR MASS OF CD27  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
T lymphocytes 110-120 kDa 55 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD27  

POST-TRANSLATIONAL MODIFICATION OF CD27  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD27   - No information

SUBSTRATES FOR CD27   - No information

ENZYMES WHICH MODIFY CD27   - No information

LIGANDS FOR CD27 AND MOLECULES ASSOCIATED WITH CD27  

MOLECULECOMMENT
CD70 Type II transmembrane molecule belonging to the TNF family
SIVA Apoptosis-inducing protein reported (Prasad et al. 1997) but not confirmed independently**
TRAF5 Involved in NF-kappaB and SAPK/JNK activation by CD27 (Akiba H et al. 1998)**
TRAF2 Involved in NF-kappaB and SAPK/JNK activation by CD27 (Akiba H et al. 1998)**

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD27  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD27  
REAGENTS
CD27-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
6T-028 (203-6) Ramon Vilella, Barcelona, SPAIN  
6T-037 (L128) Noel L Warner (Becton Dickinson), San Jose, USA  
6T-110 (1A4) Sugita K et al. 1991  

SELECTION OF OTHER CD27-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
S152 Bigler RD et al. 1988  
OKT18 Patricia Rao (Ortho), Raritan, USA  
CLB-9F4 van Lier RAW et al. 1987  
JML-H235 Mitsuo Yokoyama, Kurume, Japan  
O323 Laurence Boumsell, Paris, France  
LT27 Filatov AV et al. 1992  
143-14 Martorell J et al. 1990  
M-T271 E Peter Rieber, Munchen, Germany  
VIT14 Walter Knapp, Vienna, Austria  

 
SELECTED REFERENCES ON CD27  

REVIEWS

1. Hintzen RQ, de Jong R, Lens SM and van Lier RA. CD27: marker and mediator of T-cell activation? Immunol. Today 1994 15:307 PubMed

PRIMARY CITATIONS

2. Akiba H, et al. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. J Biol Chem. 1998 May 22; 273(21): 13353-13358 ** PubMed

3. Agematsu K, Kobata T, Sugita K, Hirose T, Schlossman SF and Morimoto C. Direct cellular communications between CD45R0 and CD45RA T cell subsets via CD27/CD70. J. Immunol. 1995 154:3627 PubMed

4. Bigler RD, Bushkin Y and Chiorazzi N. S152 (CD27). A modulating disulfide-linked T cell activation antigen. J. Immunol. 1988 141:21 PubMed

5. Camerini D, Walz G, Loenen WA, Borst J and Seed B. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. J. Immunol. 1991 147:3165 PubMed

6. Gravestein LA, van Ewijk W, Ossendorp F and Borst J. CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development. J. Exp. Med. 1996 184:675 PubMed

7. Jacquot S, Kobata T, Iwata S, Morimoto C and Schlossman SF. CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signaling. J. Immunol. 1997 159:2652 PubMed

8. Kobata T, Agematsu K, Kameoka J, Schlossman SF and Morimoto C. CD27 is a signal-transducing molecule involved in CD45RA+ naive T cell costimulation. J. Immunol. 1994 153:5422 PubMed

9. Kobata T, Jacquot S, Kozlowski S, Agematsu K, Schlossman SF and Morimoto C. CD27-CD70 interactions regulate B-cell activation by T cells. Proc. Natl. Acad. Sci. U.S.A. 1995 92:11249 PubMed

10. Loenen WA, De Vries E, Gravestein LA, Hintzen RQ, Van Lier RA and Borst J. The CD27 membrane receptor, a lymphocyte-specific member of the nerve growth factor receptor family, gives rise to a soluble form by protein processing that does not involve receptor endocytosis. Eur. J. Immunol. 1992 22:447 PubMed

11. Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S and Schlossman SF. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc. Natl. Acad. Sci. U.S.A. 1997 94:6346 PubMed

12. Sugita K, Torimoto Y, Nojima Y, Daley JF, Schlossman SF and Morimoto C. The 1A4 molecule (CD27) is involved in T cell activation. J. Immunol. 1991 147:1477 PubMed

13. van Lier RA, Borst J, Vroom TM, Klein H, Van Mourik P, Zeijlemaker WP and Melief CJ. Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. J. Immunol. 1987 139:1589 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov