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PROW: CD62L
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD62L
Author: Kiyoshi Goda
Reviewer: Thomas F. Tedder
[GUIDE BAR]

ALTERNATE NAMES FOR CD62L  

MAJOR LINKS FOR CD62L  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD62L   - Unknown

CELLULAR FUNCTION OF CD62L  

DISEASE RELEVANCE OF CD62L AND FUNCTION OF CD62L IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD62L  

MOLECULAR STRUCTURE OF CD62L  

MOLECULAR MASS OF CD62L  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Neutrophil   95kDa  
Lymphocyte 65kDa 74kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD62L   - Unknown

POST-TRANSLATIONAL MODIFICATION OF CD62L  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD62L   - Unknown

SUBSTRATES FOR CD62L   - Unknown

ENZYMES WHICH MODIFY CD62L   - Unknown

LIGANDS FOR CD62L AND MOLECULES ASSOCIATED WITH CD62L  

MOLECULECOMMENT
CD34 Note 1
GlyCAM-1 Note 1
MAdCAM-1 Note 1

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD62L  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD62L   - No information


REAGENTS
CD62L-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
MHL1 (A044) Miyaura S, Tokyo  
MHL2 (A045) Miyaura S, Tokyo  
MHL3 (A046) Miyaura S, Tokyo  

SELECTION OF OTHER CD62L-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
Dreg-56 Kishimoto TK et al. 1990  

 
SELECTED REFERENCES ON CD62L  

REVIEWS

PRIMARY CITATIONS

1. Chen A,Engel P,Tedder TF Structural requirements regulate endoproteolytic release of the L- selectin (CD62L) adhesion receptor from the cell surface of leukocytes. J Exp Med 1995 182:519 PubMed

2. Griffin JD,Spertini O,Ernst TJ,Belvin MP,Levine HB,Kanakura Y,Tedder TF Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. J Immunol 1990 145:576 PubMed

3. Migaki GI,Kahn J,Kishimoto TK Mutational analysis of the membrane-proximal cleavage site of L- selectin: relaxed sequence specificity surrounding the cleavage site. J Exp Med 1995 182:549 PubMed

4. Spertini O,Freedman AS,Belvin MP,Penta AC,Griffin JD,Tedder TF Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells. Leukemia 1991 5:300 PubMed

5. Spertini O,Luscinskas FW,Gimbrone MA Jr,Tedder TF Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. J Exp Med 1992 175:1789 PubMed

6. Spertini O,Luscinskas FW,Kansas GS,Munro JM,Griffin JD,Gimbrone MA Jr,Tedder TF Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol 1991 147:2565 PubMed

7. Tedder TF,Isaacs CM,Ernst TJ,Demetri GD,Adler DA,Disteche CM Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. J Exp Med 1989 170:123 PubMed

8. Tedder TF,Matsuyama T,Rothstein D,Schlossman SF,Morimoto C Human antigen-specific memory T cells express the homing receptor (LAM- 1) necessary for lymphocyte recirculation. Eur J Immunol 1990 20:1351 PubMed

9. Tedder TF,Penta AC,Levine HB,Freedman AS Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens. J Immunol 1990 144:532 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov