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PROW: CD42a
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD42a
Author: Masja de Haas
Reviewer: Kenneth J. Clemetson
[GUIDE BAR]

ALTERNATE NAMES FOR CD42a  

MAJOR LINKS FOR CD42a  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD42a  

CELLULAR FUNCTION OF CD42a  

DISEASE RELEVANCE OF CD42a AND FUNCTION OF CD42a IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD42a  

MOLECULAR STRUCTURE OF CD42a  

MOLECULAR MASS OF CD42a  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Platelets 22 kDa 17-22 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD42a   - No information

POST-TRANSLATIONAL MODIFICATION OF CD42a  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD42a  
MOLECULECOMMENT
GATA-1  
Ets  

SUBSTRATES FOR CD42a   - No information

ENZYMES WHICH MODIFY CD42a   - No information

LIGANDS FOR CD42a AND MOLECULES ASSOCIATED WITH CD42a  

MOLECULECOMMENT
CD42b Forms non-covalent complex with CD42a**
CD42c Forms non-covalent complex with CD42a**
CD42d Forms non-covalent complex with CD42a**

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD42a  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD42a   - No information


REAGENTS
CD42a-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
P-34 (ALMA.16) F Lanza, Strasbourg  

SELECTION OF OTHER CD42a-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
FMC-25 H Zola, Adelaide  
BL-H6 H Fiebig, Leipzig  
GR-P F Garrido, Granada  
Sz-2 C Ruan, Jiangsu  

 
SELECTED REFERENCES ON CD42a  

REVIEWS

PRIMARY CITATIONS

1. Clemetson KJ, McGregor JL, James E, Dechavanne M and Luscher EF. Characterization of the platelet membrane glycoprotein abnormalities in Bernard-Soulier syndrome and comparison with normal by surface-labeling techniques and high-resolution two-dimensional gel electrophoresis. J. Clin. Invest. 1982 70:304 PubMed

2. Fox JE, Aggerbeck LP and Berndt MC. Structure of the glycoprotein Ib.IX complex from platelet membranes. J. Biol. Chem. 1988 263:4882 PubMed

3. Hickey MJ, Williams SA and Roth GJ. Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures. Proc. Natl. Acad. Sci. U.S.A. 1989 86:6773 PubMed

4. Muszbek L and Laposata M. Glycoprotein Ib and glycoprotein IX in human platelets are acylated with palmitic acid through thioester linkages. J. Biol. Chem. 1989 264:9716 PubMed

5. Nurden AT, Dupuis D, Kunicki TJ and Caen JP. Analysis of the glycoprotein and protein composition of Bernard-Soulier platelets by single and two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis. J. Clin. Invest. 1981 67:1431 PubMed

6. Schick PK and Walker J. The acylation of megakaryocyte proteins: glycoprotein IX is primarily myristoylated while glycoprotein Ib is palmitoylated. Blood 1996 87:1377 PubMed

7. Wicki AN and Clemetson KJ. The glycoprotein Ib complex of human blood platelets. Eur. J. Biochem. 1987 163:43 PubMed

8. Wright SD, Michaelides K, Johnson DJ, West NC and Tuddenham EG. Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome. Blood 1993 81:2339 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov