Science Gateway > Resources > Cluster of Differentiation Index

PROW: CD166
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD166
Author: Michael A. Bowen
Reviewer: Dhavalkumar D. Patel
[GUIDE BAR]

ALTERNATE NAMES FOR CD166  

MAJOR LINKS FOR CD166  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD166   - No information

CELLULAR FUNCTION OF CD166  

DISEASE RELEVANCE OF CD166 AND FUNCTION OF CD166 IN INTACT ANIMAL   - No information


STRUCTURE
MOLECULAR FAMILY FOR CD166  

MOLECULAR STRUCTURE OF CD166  

MOLECULAR MASS OF CD166  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
T cell lymphoma 100-105 kDa 100-105 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD166   - No information

POST-TRANSLATIONAL MODIFICATION OF CD166  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD166   - No information

SUBSTRATES FOR CD166   - No information

ENZYMES WHICH MODIFY CD166   - No information

LIGANDS FOR CD166 AND MOLECULES ASSOCIATED WITH CD166  

MOLECULECOMMENT
CD6 ALCAM (CD166) in the human system was first characterized as a ligand for CD6
30-35kd protein Immunoprecipitation results have shown human ALCAM (CD166) is sometimes associated with a 30-35 kDa protein
CD166 (homophilic) Chicken ALCAM (CD166) [known as BEN/DM-GRASP/SC-1] was shown to act as a homophilic adhesion molecule in the nervous system
NgCAM Chicken ALCAM (CD166) [known as BEN/DM-GRASP/SC-1] was shown to bind to NgCAM

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD166  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD166  
REAGENTS
CD166-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
J3-119 John Pesando, Seattle, WA  
J4-81 John Pesando, Seattle, WA  
3A6 Dhavalkumar D. Patel, Durham, NC  

SELECTION OF OTHER CD166-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
HAL 8.2 Bowen et al., 1996  
HAL 31.1 Bowen et al., 1996  
HAL 151 Bowen et al., 1996  

 
SELECTED REFERENCES ON CD166  

REVIEWS

PRIMARY CITATIONS

1. Bowen MA,Bajorath J,Siadak AW,Modrell B,Malacko AR,Marquardt H,Nadler SG,Aruffo A The amino-terminal immunoglobulin-like domain of activated leukocyte cell adhesion molecule binds specifically to the membrane-proximal scavenger receptor cysteine-rich domain of CD6 with a 1:1 stoichiometry. J Biol Chem 1996 271:17390 PubMed

2. Bowen MA,Patel DD,Li X,Modrell B,Malacko AR,Wang WC,Marquardt H,Neubauer M,Pesando JM,Francke U,et al Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. J Exp Med 1995 181:2213 PubMed

3. Burns FR,von Kannen S,Guy L,Raper JA,Kamholz J,Chang S DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension. Neuron 1991 7:209 PubMed

4. Corbel C,Pourquie O,Cormier F,Vaigot P,Le Douarin NM BEN/SC1/DM-GRASP, a homophilic adhesion molecule, is required for in vitro myeloid colony formation by avian hemopoietic progenitors. Proc Natl Acad Sci U S A 1996 93:2844 PubMed

5. DeBernardo AP,Chang S Heterophilic interactions of DM-GRASP: GRASP-NgCAM interactions involved in neurite extension. J Cell Biol 1996 133:657 PubMed

6. Patel DD,Wee SF,Whichard LP,Bowen MA,Pesando JM,Aruffo A,Haynes BF Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells. J Exp Med 1995 181:1563 PubMed

7. Peduzzi JD,Irwin MH,Geisert EE Jr Distribution and characteristics of a 90 kDa protein, KG-CAM, in the rat CNS. Brain Res 1994 640:296 PubMed

8. Pesando JM,Hoffman P,Abed M Antibody-induced antigenic modulation is antigen dependent: characterization of 22 proteins on a malignant human B cell line. J Immunol 1986 137:3689 PubMed

9. Pourquie O,Corbel C,Le Caer JP,Rossier J,Le Douarin NM BEN, a surface glycoprotein of the immunoglobulin superfamily, is expressed in a variety of developing systems. Proc Natl Acad Sci U S A 1992 89:5261 PubMed

10. Skonier JE,Bowen MA,Emswiler J,Aruffo A,Bajorath J Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM. Biochemistry 1996 35:12287 PubMed

11. Tanaka H,Matsui T,Agata A,Tomura M,Kubota I,McFarland KC,Kohr B,Lee A,Phillips HS,Shelton DL Molecular cloning and expression of a novel adhesion molecule, SC1. Neuron 1991 7:535 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov