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PROW: CD11c
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD11c
Author: Nancy Hogg
Reviewer: A. L. Corbi
[GUIDE BAR]

ALTERNATE NAMES FOR CD11c  

MAJOR LINKS FOR CD11c  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD11c   - No information

CELLULAR FUNCTION OF CD11c  

DISEASE RELEVANCE OF CD11c AND FUNCTION OF CD11c IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD11c  

MOLECULAR STRUCTURE OF CD11c  

MOLECULAR MASS OF CD11c  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Leukocytes 145 kDa 150 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD11c   - No information

POST-TRANSLATIONAL MODIFICATION OF CD11c  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD11c  
MOLECULECOMMENT
Sp1 and Sp1-like factors Lopez-Rodriguez C et al 1996**
AP-1 family Lopez-Rodriguez C et at 1997, Noti J et al. 1996**
C/EBP Corbi AL 1996**
Oct-2 Corbi AL 1996**
PU.1 Corbi AL 1996**

SUBSTRATES FOR CD11c   - No information

ENZYMES WHICH MODIFY CD11c   - No information

LIGANDS FOR CD11c AND MOLECULES ASSOCIATED WITH CD11c  

MOLECULECOMMENT
iC3b Ligand
Fibrinogen Ligand
(ICAM-1)  
(CD23)  
LPS/LPB (Cis interactions?-see Petty and Todd, 1996)
uPAR(?) (Cis interactions?-see Petty and Todd, 1996)

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD11c  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD11c  
REAGENTS
CD11c-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
B-ly5 S Poppema  
U4 JH Peters  

SELECTION OF OTHER CD11c-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
SHCL3 R Schwarting  
L29 L Lanier  
3.9 N Hogg  
KB23 K Pulford  
BU15 DL Hardie  
HC1/1 C Bernabeu**  

 
SELECTED REFERENCES ON CD11c  

REVIEWS

1. Corbi, A.L. In 'Leukocyte Integrins: structure, expression and function'.Springer (Heidelberg, Germany)/R.G. Landes (Gergetown, Texas) Ed, 1996 **

2. Petty HR,Todd RF 3d Integrins as promiscuous signal transduction devices. Immunol Today 1996 17:209 PubMed

3. Springer TA Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994 76:301 PubMed

4. Stewart M,Thiel M,Hogg N Leukocyte integrins. Curr Opin Cell Biol 1995 7:690 PubMed

PRIMARY CITATIONS

5. Corbi AL,Miller LJ,O'Connor K,Larson RS,Springer TA cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95. EMBO J 1987 6:4023 PubMed

6. Coxon A,Rieu P,Barkalow FJ,Askari S,Sharpe AH,von Andrian UH,Arnaout MA,Mayadas TN A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 1996 5:653 ** PubMed

7. Lopez-Rodriguez C,Chen HM,Tenen DG,Corbi AL Identification of Sp1-binding sites in the CD11c (p150,95 alpha) and CD11a (LFA-1 alpha) integrin subunit promoters and their involvement in the tissue-specific expression of CD11c. Eur J Immunol 1995 25:3496 PubMed

8. Lopez-Rodriguez C,Kluin-Nelemans HC,Corbi AL AP-1 regulates the basal and developmentally induced transcription of the CD11c leukocyte integrin gene. J Immunol 1996 156:3780 PubMed

9. Noti JD,Reinemann BC,Petrus MN Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with AP1 to activate transcription. Mol Cell Biol 1996 16:2940 PubMed

10. Sanchez-Madrid F,Nagy JA,Robbins E,Simon P,Springer TA A human leukocyte differentiation antigen family with distinct alpha- subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule. J Exp Med 1983 158:1785 PubMed

11. Springer TA Folding of the N-terminal, ligand-binding region of integrin alpha- subunits into a beta-propeller domain. Proc Natl Acad Sci U S A 1997 94:65 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov