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PROW: CD19
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PROW and IWHLDA present the GUIDE on:
CD19
Authors: Shinichi Sato; Thomas F. Tedder
Reviewer: Douglas T. Fearon
[GUIDE BAR]

ALTERNATE NAMES FOR CD19  

MAJOR LINKS FOR CD19  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD19  

CELLULAR FUNCTION OF CD19  

DISEASE RELEVANCE OF CD19 AND FUNCTION OF CD19 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD19  

MOLECULAR STRUCTURE OF CD19  

MOLECULAR MASS OF CD19  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
B cell >120 kDa 95 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD19   - None

POST-TRANSLATIONAL MODIFICATION OF CD19  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD19  
MOLECULECOMMENT
Pax-5 (BSAP)  

SUBSTRATES FOR CD19   - No information

ENZYMES WHICH MODIFY CD19   - No information

LIGANDS FOR CD19 AND MOLECULES ASSOCIATED WITH CD19  

MOLECULECOMMENT
CD21 (CR2) The extracellular AND transmembrane region of CD19 are required for association with CD21 (Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes. (Matsumoto AK et al. 1993)*
CD81 (TAPA-1) Member of the tetra-spans family that associates directly with CD19 in a non-covalent manner within the membrane proximal extracellular region of CD19
Leu-13 Interferon inducible gene product that associates directly with CD81 and thereby associates with CD19 indirectly
lyn The extensive cytoplasmic domain of CD19 is reported to associate with lyn, lck, fyn and phosphoinositide 3-kinase following tyrosine phosphorylation of CD19
fyn The extensive cytoplasmic domain of CD19 is reported to associate with lyn, lck, fyn and phosphoinositide 3-kinase following tyrosine phosphorylation of CD19
PI-3K phosphoinositide 3-kinase The extensive cytoplasmic domain of CD19 is reported to associate with lyn, lck, fyn and phosphoinositide 3-kinase following tyrosine phosphorylation of CD19
Vav The tyrosine phosphorylated cytoplasmic domain of CD19 also associated with Vav (Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors. Weng WK et al. 1994), an association that is likely to biologically quite important**

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD19  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD19  
REAGENTS
CD19-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
386.12 (CD19.1) A van Agthoven, France  
PDR38 (CD19.2) K Pulford, England  
B022 (AE1) S Funderud, Norway  
B077 (ZCH-4-2E8) Tang  

SELECTION OF OTHER CD19-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
B4 LM Nadler, Boston  
HB12b TF Tedder, Durham  

 
SELECTED REFERENCES ON CD19  

REVIEWS

1. Tedder TF,Zhou LJ,Engel P The CD19/CD21 signal transduction complex of B lymphocytes. Immunol Today 1994 15:437 PubMed

PRIMARY CITATIONS

2. Bradbury LE,Kansas GS,Levy S,Evans RL,Tedder TF The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. J Immunol 1992 149:2841 PubMed

3. Carter RH,Fearon DT CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 1992 256:105 PubMed

4. Carter RH,Tuveson DA,Park DJ,Rhee SG,Fearon DT The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex. J Immunol 1991 147:3663 PubMed

5. Engel P,Zhou LJ,Ord DC,Sato S,Koller B,Tedder TF Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 1995 3:39 PubMed

6. Matsumoto AK,Kopicky-Burd J,Carter RH,Tuveson DA,Tedder TF,Fearon DT Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19. J Exp Med 1991 173:55 PubMed

7. Nadler LM,Anderson KC,Marti G,Bates M,Park E,Daley JF,Schlossman SF B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol 1983 131:244 PubMed

8. Pezzutto A,Dorken B,Rabinovitch PS,Ledbetter JA,Moldenhauer G,Clark EA CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation. J Immunol 1987 138:2793 PubMed

9. Rickert RC,Rajewsky K,Roes J Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 1995 376:352 PubMed

10. Sato S,Steeber DA,Tedder TF The CD19 signal transduction molecule is a response regulator of B- lymphocyte differentiation. Proc Natl Acad Sci U S A 1995 92:11558 PubMed

11. Steeber DA,Green NE,Sato S,Tedder TF Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system. J Immunol 1996 157:1096 PubMed

12. Tedder TF,Isaacs CM Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. J Immunol 1989 143:712 PubMed

13. Tuveson DA,Carter RH,Soltoff SP,Fearon DT CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 1993 260:986 PubMed

14. Weng WK,Jarvis L,LeBien TW Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3- kinase complex in human B cell precursors. J Biol Chem 1994 269:32514 PubMed

15. Zhou LJ,Smith HM,Waldschmidt TJ,Schwarting R,Daley J,Tedder TF Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development. Mol Cell Biol 1994 14:3884 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/14/99   mpr@mail.nih.gov