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PROW: CD87
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD87
Author: Robert Todd
Reviewer: Douglas B. Cines
[GUIDE BAR]

ALTERNATE NAMES FOR CD87  

MAJOR LINKS FOR CD87  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD87  

CELLULAR FUNCTION OF CD87  

DISEASE RELEVANCE OF CD87 AND FUNCTION OF CD87 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD87  

MOLECULAR STRUCTURE OF CD87  

MOLECULAR MASS OF CD87  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
U-937 cells 41-68 kDa 39-66 kDa  
Monocytes 35-59 kDa 32-56 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD87  

POST-TRANSLATIONAL MODIFICATION OF CD87  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD87   - No information

SUBSTRATES FOR CD87   - No information

ENZYMES WHICH MODIFY CD87   - No information

LIGANDS FOR CD87 AND MOLECULES ASSOCIATED WITH CD87  

MOLECULECOMMENT
uPA CD87 serves as a receptor for pro-uPA and uPA with high affinity (Kd 10-9- 10-10 molar)
Pro-uPA See uPA
Vitronectin CD87 ligand

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD87  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD87  
REAGENTS
CD87-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
IIIF10 (MA69) Luther T et al. 1996  
IID7 (MA70) Luther T et al. 1996  
HD-uPA-R 13.1 (MA71) Schaefer B et al. 1995  
HD-uPA-R 15.4.1 (MA72) Michael Kramer, Heidelberg  

SELECTION OF OTHER CD87-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
anti-Mo3f (MR20) Mizukami I F et al. 1990  
VIM5 (MA73) Gadd S J et al. 1990  

 
SELECTED REFERENCES ON CD87  

REVIEWS

1. Dano, K et al. 1994. Fibrinolysis 8: 189-203.

2. Petty HR,Todd RF 3d Integrins as promiscuous signal transduction devices. Immunol Today 1996 17:209 PubMed

3. Vassalli, J D. 1994. Fibrinolysis 8: 172-181.

PRIMARY CITATIONS

4. Gadd SJ,Majdic O,Kasinrerk W,Stockinger H,Maurer D,Eher R,Knapp W M5, a phosphoinositol-linked human myelomonocytic activation-associated antigen. Clin Exp Immunol 1990 80:252 PubMed

5. Gyetko MR,Sitrin RG,Fuller JA,Todd RF 3rd,Petty H,Standiford TJ Function of the urokinase receptor (CD87) in neutrophil chemotaxis. J Leukoc Biol 1995 58:533 PubMed

6. Luther T,Magdolen V,Albrecht S,Kasper M,Riemer C,Kessler H,Graeff H,Muller M,Schmitt M Epitope-mapped monoclonal antibodies as tools for functional and morphological analyses of the human urokinase receptor in tumor tissue. Am J Pathol 1997 150:1231 PubMed

7. Mizukami IF,Vinjamuri SD,Trochelman RD,Todd RF 3d A structural characterization of the Mo3 activation antigen expressed on the plasma membrane of human mononuclear phagocytes. J Immunol 1990 144:1841 PubMed

8. Schaefer BM,Stark HJ,Fusenig NE,Todd RF 3rd,Kramer MD Differential expression of urokinase-type plasminogen activator (uPA), its receptor (uPA-R), and inhibitor type-2 (PAI-2) during differentiation of keratinocytes in an organotypic coculture system. Exp Cell Res 1995 220:415 PubMed

9. Wei Y,Waltz DA,Rao N,Drummond RJ,Rosenberg S,Chapman HA Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem 1994 269:32380 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/14/99   mpr@mail.nih.gov