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PROW: CD146
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD146
Authors: Francoise Dignat-George; Jose Sampol
Reviewer: Judith P. Johnson
[GUIDE BAR]

ALTERNATE NAMES FOR CD146  

MAJOR LINKS FOR CD146  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD146   - Unknown

CELLULAR FUNCTION OF CD146   - Potential adhesion molecule

DISEASE RELEVANCE OF CD146 AND FUNCTION OF CD146 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD146  

MOLECULAR STRUCTURE OF CD146  

MOLECULAR MASS OF CD146  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
ENDOTHELIUM      
Melanoma** 118kDa 130 kDa  
Glioma** 118kDa 130 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD146   - Unknown

POST-TRANSLATIONAL MODIFICATION OF CD146  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD146   - Unknown

SUBSTRATES FOR CD146   - Unknown

ENZYMES WHICH MODIFY CD146   - Unknown

LIGANDS FOR CD146 AND MOLECULES ASSOCIATED WITH CD146   - Unknown


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD146  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD146  
REAGENTS
CD146-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
F4-35H7 (E057) Dignat-George / Sampol  
F4-39E10 (E058) Dignat-George / Sampol  
F4-32G3 (E059) Dignat-George / Sampol  
541/10B2(E065) Knapp  
541/2E5 (E066) Knapp  
OJ79 (E067) Simmons  
OJ91 (E068) Simmons  
TEA 1/34 (E077) Sanchez - Madrid  
TEA 1/8 (E078) Sanchez - Madrid  

SELECTION OF OTHER CD146-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
Muc 18 Johnson  
Muc BA 18.2 Johnson  
Muc BA 18.3 Johnson  
Muc BA 18.4 Johnson  
E1-4 E3 Johnson  
1 Herlyn  
MN 3 Herlyn  
MN 4 Herlyn  
MN 5 Herlyn  
MN 6 Herlyn  
7 Herlyn  
MN 8 Herlyn  
MN 9 Herlyn  
MN 11 Herlyn  
MN 12 Herlyn  
MN 15 Herlyn  
MN 16 Herlyn  
MN 18 Herlyn  
MN 19 Herlyn  
A32 Herlyn  

 
SELECTED REFERENCES ON CD146  

REVIEWS

1. Johnson JP,Rummel MM,Rothbacher U,Sers C MUC18: A cell adhesion molecule with a potential role in tumor growth and tumor cell dissemination. Curr Top Microbiol Immunol 1996 213:95 ** PubMed

PRIMARY CITATIONS

2. Bardin N,George F,Mutin M,Brisson C,Horschowski N,Frances V,Lesaule G,Sampol J S-Endo 1, a pan-endothelial monoclonal antibody recognizing a novel human endothelial antigen. Tissue Antigens 1996 48:531 PubMed

3. George F,Brouqui P,Boffa MC,Mutin M,Drancourt M,Brisson C,Raoult D,Sampol J Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. Blood 1993 82:2109 PubMed

4. George, F., Mutin, M., Laurent, J.C., Poncelet, P., Sampol, J. In: Leucocyte Typing V (S. Drew et al Eds), Oxford University Press, Boston 1848, 1798-801 (1995)

5. Lehmann JM,Holzmann B,Breitbart EW,Schmiegelow P,Riethmuller G,Johnson JP Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000. Cancer Res 1987 47:841 PubMed

6. Lehmann JM,Riethmuller G,Johnson JP MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc Natl Acad Sci U S A 1989 86:9891 PubMed

7. Pickl WF,Majdic O,Fischer GF,Petzelbauer P,Fae I,Waclavicek M,Stockl J,Scheinecker C,Vidicki T,Aschauer H,Johnson JP,Knapp W MUC18/MCAM (CD146), an activation antigen of human T lymphocytes. J Immunol 1997 158:2107 PubMed

8. Rummel MM,Sers C,Johnson JP Phorbol ester and cyclic AMP-mediated regulation of the melanoma- associated cell adhesion molecule MUC18/MCAM. Cancer Res 1996 56:2218 PubMed

9. Sers C,Kirsch K,Rothbacher U,Riethmuller G,Johnson JP Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. Proc Natl Acad Sci U S A 1993 90:8514 PubMed

10. Shih IM,Elder DE,Hsu MY,Herlyn M Regulation of Mel-CAM/MUC18 expression on melanocytes of different stages of tumor progression by normal keratinocytes. Am J Pathol 1994 145:837 PubMed

11. Shih IM,Kurman RJ Expression of melanoma cell adhesion molecule in intermediate trophoblast. Lab Invest 1996 75:377 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov