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PROW: CD49d
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PROW and IWHLDA present the GUIDE on:
CD49d
Author: Yoshiya Tanaka
Reviewer: Francisco Sanchez-Madrid
[GUIDE BAR]

ALTERNATE NAMES FOR CD49d  

MAJOR LINKS FOR CD49d  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD49d  

CELLULAR FUNCTION OF CD49d  

DISEASE RELEVANCE OF CD49d AND FUNCTION OF CD49d IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD49d  

MOLECULAR STRUCTURE OF CD49d  

MOLECULAR MASS OF CD49d  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Lymphocytes 145 kDa, (180 kDa) 150 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD49d   - Unknown

POST-TRANSLATIONAL MODIFICATION OF CD49d  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD49d   - Unknown

SUBSTRATES FOR CD49d   - No information

ENZYMES WHICH MODIFY CD49d   - Unknown

LIGANDS FOR CD49d AND MOLECULES ASSOCIATED WITH CD49d  

MOLECULECOMMENT
CD106 (VCAM-1) Ligand for a4b1 and a4b7
MAdCAM-1 Ligand for a4b7
Fibronectin (CS-1) Ligand for a4b1 and a4b7, both Cys278 and Cys717 are required
Invasin Microbial ligand
Thrombospondin a4b1

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD49d  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD49d   - No information


REAGENTS
CD49d-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - None

SELECTION OF OTHER CD49d-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
HP2/1 (CD49d) Ref. 21  
9F10 (CD49d) Ref. 22  

 
SELECTED REFERENCES ON CD49d  

REVIEWS

1. Elices, M.J. ed. 1995. Springer Semin. Immunopathol. 16. Number 4 **

2. Hemler ME, Kassner P, Bodorova J. In Leukocyte typin V (ed SF Schlossman et al.), pp1617-18. Oxford University Press, Oxford (1993).

3. Lobb RR,Hemler ME The pathophysiologic role of alpha 4 integrins in vivo. J Clin Invest 1994 94:1722 PubMed

PRIMARY CITATIONS

4. Alon R,Kassner PD,Carr MW,Finger EB,Hemler ME,Springer TA The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 1995 128:1243 PubMed

5. Arroyo AG,Yang JT,Rayburn H,Hynes RO Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Cell 1996 85:997 ** PubMed

6. Berlin C,Berg EL,Briskin MJ,Andrew DP,Kilshaw PJ,Holzmann B,Weissman IL,Hamann A,Butcher EC Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993 74:185 PubMed

7. Ennis E,Isberg RR,Shimizu Y Very late antigen 4-dependent adhesion and costimulation of resting human T cells by the bacterial beta 1 integrin ligand invasin. J Exp Med 1993 177:207 PubMed

8. Maguire JE,Danahey KM,Burkly LC,van Seventer GA T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells. J Exp Med 1995 182:2079 PubMed

9. Masumoto A,Hemler ME Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, J Cell Biol 1993 123:245 PubMed

10. Pulido R,Elices MJ,Campanero MR,Osborn L,Schiffer S,Garcia-Pardo A,Lobb R,Hemler ME,Sanchez-Madrid F Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes. J Biol Chem 1991 266:10241 ** PubMed

11. Schweighoffer T,Tanaka Y,Tidswell M,Erle DJ,Horgan KJ,Luce GE,Lazarovits AI,Buck D,Shaw S Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism. J Immunol 1993 151:717 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov