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PROW: CD114
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD114
Author: Brigitte Kasper
Reviewer: Ivo P. Touw
[GUIDE BAR]

ALTERNATE NAMES FOR CD114  

MAJOR LINKS FOR CD114  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD114  

CELLULAR FUNCTION OF CD114  

DISEASE RELEVANCE OF CD114 AND FUNCTION OF CD114 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD114  

MOLECULAR STRUCTURE OF CD114  

MOLECULAR MASS OF CD114  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Granulocytes   130  

POST-TRANSCRIPTIONAL MODIFICATION OF CD114  

POST-TRANSLATIONAL MODIFICATION OF CD114  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD114  
MOLECULECOMMENT
PU.1 Regulates CD114(G-CSFR) promoter in myeloid cells
C/EBP[alpha] Regulates CD114(G-CSFR) promoter in myeloid cells

SUBSTRATES FOR CD114   - No information

ENZYMES WHICH MODIFY CD114   - No information

LIGANDS FOR CD114 AND MOLECULES ASSOCIATED WITH CD114  

MOLECULECOMMENT
G-CSF Cytokine ligand
Jak1 Phosphorylation of the kinases regulates G-CSFR activity
Jak2 Phosphorylation of the kinases regulates G-CSFR activity

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD114  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD114   - No information


REAGENTS
CD114-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
129 (MR22) Kasper B et al. 1995  
LMM741 (MA98) Nicholson SE et al. 1994  

SELECTION OF OTHER CD114-SPECIFIC REFERENCE MAB   - No information


 
SELECTED REFERENCES ON CD114  

REVIEWS

1. Avalos BR Molecular analysis of the granulocyte colony-stimulating factor receptor. Blood 1996 88:761 PubMed

PRIMARY CITATIONS

2. Bernard T,Gale RE,Linch DC Analysis of granulocyte colony stimulating factor receptor isoforms, polymorphisms and mutations in normal haemopoietic cells and acute myeloid leukaemia blasts. Br J Haematol 1996 93:527 PubMed

3. Bussolino F,Wang JM,Defilippi P,Turrini F,Sanavio F,Edgell CJ,Aglietta M,Arese P,Mantovani A Granulocyte- and granulocyte-macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate. Nature 1989 337:471 PubMed

4. Dong F,Brynes RK,Tidow N,Welte K,Lowenberg B,Touw IP Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N Engl J Med 1995 333:487 PubMed

5. Fukunaga R,Ishizaka-Ikeda E,Pan CX,Seto Y,Nagata S Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J 1991 10:2855 PubMed

6. Fukunaga R,Seto Y,Mizushima S,Nagata S Three different mRNAs encoding human granulocyte colony-stimulating factor receptor. Proc Natl Acad Sci U S A 1990 87:8702 PubMed

7. Kasper B, Hadam MR, and Welte K (1995), Blood 86 (Suppl.1), 510a.

8. Nicholson SE,Oates AC,Harpur AG,Ziemiecki A,Wilks AF,Layton JE Tyrosine kinase JAK1 is associated with the granulocyte-colony- stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. Proc Natl Acad Sci U S A 1994 91:2985 PubMed

9. Rauprich P,Kasper B,Tidow N,Welte K The protein tyrosine kinase JAK2 is activated in neutrophils from patients with severe congenital neutropenia. Blood 1995 86:4500 PubMed

10. Smith LT,Hohaus S,Gonzalez DA,Dziennis SE,Tenen DG PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony- stimulating factor receptor promoter in myeloid cells. Blood 1996 88:1234 PubMed

11. Souza LM,Boone TC,Gabrilove J,Lai PH,Zsebo KM,Murdock DC,Chazin VR,Bruszewski J,Lu H,Chen KK,et al Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science 1986 232:61 PubMed

12. Uzumaki H,Okabe T,Sasaki N,Hagiwara K,Takaku F,Tobita M,Yasukawa K,Ito S,Umezawa Y Identification and characterization of receptors for granulocyte colony- stimulating factor on human placenta and trophoblastic cells. Proc Natl Acad Sci U S A 1989 86:9323 PubMed

13. Ziegler SF,Bird TA,Morella KK,Mosley B,Gearing DP,Baumann H Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction. Mol Cell Biol 1993 13:2384 PubMed

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* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov