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PROW: CD66c
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD66c
Authors: Keith Skubitz; Peter Jantscheff; Motomu Kuroki; Amy Skubitz
Reviewer:
Diverse coauthors in lieu of reviewer
Link to additional info in FORUM
[GUIDE BAR]

ALTERNATE NAMES FOR CD66c  

MAJOR LINKS FOR CD66c  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD66c   - Unclear, see ligands

CELLULAR FUNCTION OF CD66c  

DISEASE RELEVANCE OF CD66c AND FUNCTION OF CD66c IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD66c  

MOLECULAR STRUCTURE OF CD66c  

MOLECULAR MASS OF CD66c  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Various cells   90 kDa  

POST-TRANSCRIPTIONAL MODIFICATION OF CD66c  

POST-TRANSLATIONAL MODIFICATION OF CD66c  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD66c   - No information

SUBSTRATES FOR CD66c   - No information

ENZYMES WHICH MODIFY CD66c   - No information

LIGANDS FOR CD66c AND MOLECULES ASSOCIATED WITH CD66c Link to additional info in FORUM  

MOLECULECOMMENT
Unknown molecule on bacteria Binds the carbohydrate on CD66c not the protein core
CD62E (E-selectin) Binds the carbohydrate on CD66c not the protein core
Galectins Binds the carbohydrate on CD66c not the protein core
CD66a Binds the protein core of CD66c not the carbohydrate
CD66b Binds the protein core of CD66c not the carbohydrate
CD66c Binds the protein core of CD66c not the carbohydrate
CD66e Binds the protein core of CD66c not the carbohydrate
src family kinases Some src family kinases associate with CD66c in neutrophils

EXPRESSION
MAIN CELLULAR EXPRESSION OF CD66c  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD66c  
REAGENTS
CD66c-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP   - See reference mAb

SELECTION OF OTHER CD66c-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
9A6 J Johnson and Fritz Grunert,  

 
SELECTED REFERENCES ON CD66c  

REVIEWS

PRIMARY CITATIONS

1. Kleist S von,Chavanel G,Burtin P Identification of an antigen from normal human tissue that crossreacts with the carcinoembryonic antigen. Proc Natl Acad Sci U S A 1972 69:2492 PubMed

2. Thompson JA,Grunert F,Zimmermann W Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 1991 5:344 PubMed

3. Audette M,Buchegger F,Schreyer M,Mach JP Monoclonal antibody against carcinoembryonic antigen (CEA) identifies two new forms of crossreacting antigens of molecular weight 90,000 and 160,000 in normal granulocytes. Mol Immunol 1987 24:1177 PubMed

4. Tawaragi Y,Oikawa S,Matsuoka Y,Kosaki G,Nakazato H Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence. Biochem Biophys Res Commun 1988 150:89 PubMed

5. Oikawa S,Inuzuka C,Kuroki M,Matsuoka Y,Kosaki G,Nakazato H Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. Biochem Biophys Res Commun 1989 164:39 PubMed

6. Leusch HG,Hefta SA,Drzeniek Z,Hummel K,Markos-Pusztai Z,Wagener C Escherichia coli of human origin binds to carcinoembryonic antigen (CEA) and non-specific crossreacting antigen (NCA). FEBS Lett 1990 261:405 PubMed

7. Kuijpers TW,Hoogerwerf M,van der Laan LJ,Nagel G,van der Schoot CE,Grunert F,Roos D CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. J Cell Biol 1992 118:457 PubMed

8. Skubitz KM,Campbell KD,Ahmed K,Skubitz AP CD66 family members are associated with tyrosine kinase activity in human neutrophils. J Immunol 1995 155:5382 PubMed

9. Ohannesian DW,Lotan D,Thomas P,Jessup JM,Fukuda M,Gabius HJ,Lotan R Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells. Cancer Res 1995 55:2191 PubMed

10. Skubitz KM,Campbell KD,Skubitz AP CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. J Leukoc Biol 1996 60:106 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

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Modified 10/14/99   mpr@mail.nih.gov