Science Gateway > Resources > Cluster of Differentiation Index

PROW: CDw136
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CDw136
Author: Ming-Hai Wang
Reviewer: Richard Breathnach
[GUIDE BAR]

ALTERNATE NAMES FOR CDw136  

MAJOR LINKS FOR CDw136  


FUNCTION
BIOCHEMICAL ACTIVITY OF CDw136  

CELLULAR FUNCTION OF CDw136  

DISEASE RELEVANCE OF CDw136 AND FUNCTION OF CDw136 IN INTACT ANIMAL   - Unknown


STRUCTURE
MOLECULAR FAMILY FOR CDw136  

MOLECULAR STRUCTURE OF CDw136  

MOLECULAR MASS OF CDw136  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Epithelial cells 180 kDa 150 kDa (alpha chain), 40 kDa (beta chain)  
Resident macrophages 180 kDa 150 kDa (alpha chain) and 40 kDa (beta chain)  

POST-TRANSCRIPTIONAL MODIFICATION OF CDw136  

POST-TRANSLATIONAL MODIFICATION OF CDw136  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CDw136   - No information

SUBSTRATES FOR CDw136  

MOLECULECOMMENT
Grb2/Sos Translocation from cytosol to membrane and activation of Ras
PI-3 kinase Interaction with activated Receptors and involvement in cell migration

ENZYMES WHICH MODIFY CDw136   - No information

LIGANDS FOR CDw136 AND MOLECULES ASSOCIATED WITH CDw136  

MOLECULECOMMENT
MSP (macrophage stimulating protein) A name given to a purified serum protein which induces migration and shape change of mouse peritoneal resident macrophages
HGFl (hepatocyte growth factor-like) A cloned gene encoding an unknown protein with similar structure to HGF
PLC-g Association, possible substrate
Shc Association, possible substrate

EXPRESSION
MAIN CELLULAR EXPRESSION OF CDw136  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CDw136  
REAGENTS
CDw136-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
C-1 (ID1) Immunotech-Coulter, Marseille, France  
C-2 (ID2) Immunotech-Coulter, Marseille, France  

SELECTION OF OTHER CDw136-SPECIFIC REFERENCE MAB   - None


 
SELECTED REFERENCES ON CDw136  

REVIEWS

PRIMARY CITATIONS

1. Collesi C,Santoro MM,Gaudino G,Comoglio PM A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol Cell Biol 1996 16:5518 PubMed

2. Gaudino G,Avantaggiato V,Follenzi A,Acampora D,Simeone A,Comoglio PM The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues. Oncogene 1995 11:2627 PubMed

3. Gaudino G,Follenzi A,Naldini L,Collesi C,Santoro M,Gallo KA,Godowski PJ,Comoglio PM RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J 1994 13:3524 PubMed

4. Han S,Stuart LA,Degen SJ Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. Biochemistry 1991 30:9768 PubMed

5. Iwama A,Okano K,Sudo T,Matsuda Y,Suda T Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells. Blood 1994 83:3160 PubMed

6. Iwama A,Yamaguchi N,Suda T STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. EMBO J 1996 15:5866 PubMed

7. Li BQ,Wang MH,Kung HF,Ronsin C,Breathnach R,Leonard EJ,Kamata T Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor. Biochem Biophys Res Commun 1995 216:110 PubMed

8. Medico E,Mongiovi AM,Huff J,Jelinek MA,Follenzi A,Gaudino G,Parsons JT,Comoglio PM The tyrosine kinase receptors Ron and Sea control 'scattering' and morphogenesis of liver progenitor cells in vitro. Mol Biol Cell 1996 7:495 PubMed

9. Quantin B,Schuhbaur B,Gesnel MC,Doll'e P,Breathnach R Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse development. Dev Dyn 1995 204:383 * PubMed

10. Ronsin C,Muscatelli F,Mattei MG,Breathnach R A novel putative receptor protein tyrosine kinase of the met family. Oncogene 1993 8:1195 PubMed

11. Skeel A,Yoshimura T,Showalter SD,Tanaka S,Appella E,Leonard EJ Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. J Exp Med 1991 173:1227 PubMed

12. Wang MH,Cox GW,Yoshimura T,Sheffler LA,Skeel A,Leonard EJ Macrophage-stimulating protein inhibits induction of nitric oxide production by endotoxin- or cytokine-stimulated mouse macrophages. J Biol Chem 1994 269:14027 PubMed

13. Wang MH,Dlugosz AA,Sun Y,Suda T,Skeel A,Leonard EJ Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes. Exp Cell Res 1996 226:39 PubMed

14. Wang MH,Gonias SL,Skeel A,Wolf BB,Yoshimura T,Leonard EJ Proteolytic activation of single-chain precursor macrophage-stimulating protein by nerve growth factor-gamma and epidermal growth factor- binding protein, members of the kallikrein family. J Biol Chem 1994 269:13806 PubMed

15. Wang MH,Iwama A,Skeel A,Suda T,Leonard EJ The murine stk gene product, a transmembrane protein tyrosine kinase, is a receptor for macrophage-stimulating protein. Proc Natl Acad Sci U S A 1995 92:3933 PubMed

16. Wang MH,Montero-Julian FA,Dauny I,Leonard EJ Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein. Oncogene 1996 13:2167 PubMed

17. Wang MH,Ronsin C,Gesnel MC,Coupey L,Skeel A,Leonard EJ,Breathnach R Identification of the ron gene product as the receptor for the human macrophage stimulating protein. Science 1994 266:117 PubMed

18. Wang MH,Skeel A,Leonard EJ Proteolytic cleavage and activation of pro-macrophage-stimulating protein by resident peritoneal macrophage membrane proteases. J Clin Invest 1996 97:720 PubMed

19. Wang MH,Yoshimura T,Skeel A,Leonard EJ Proteolytic conversion of single chain precursor macrophage-stimulating protein to a biologically active heterodimer by contact enzymes of the coagulation cascade. J Biol Chem 1994 269:3436 PubMed

20. Yoshimura T,Yuhki N,Wang MH,Skeel A,Leonard EJ Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3. J Biol Chem 1993 268:15461 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov