Science Gateway > Resources > Cluster of Differentiation Index

PROW: CDw125
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CDw125
Author: Kiyoshi Takatsu
Reviewer: Atsushi Miyajima
[GUIDE BAR]

ALTERNATE NAMES FOR CDw125  

MAJOR LINKS FOR CDw125  


FUNCTION
BIOCHEMICAL ACTIVITY OF CDw125   - No information

CELLULAR FUNCTION OF CDw125  

DISEASE RELEVANCE OF CDw125 AND FUNCTION OF CDw125 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CDw125  

MOLECULAR STRUCTURE OF CDw125  

MOLECULAR MASS OF CDw125  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Eosinophils 60 kDa    

POST-TRANSCRIPTIONAL MODIFICATION OF CDw125  

POST-TRANSLATIONAL MODIFICATION OF CDw125  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CDw125   - No information

SUBSTRATES FOR CDw125   - No information

ENZYMES WHICH MODIFY CDw125   - No information

LIGANDS FOR CDw125 AND MOLECULES ASSOCIATED WITH CDw125  

MOLECULECOMMENT
IL-5 (Interleukin-5)  
CDw131 High affinity Il-5 receptor consists of CDw125 and CDw31

EXPRESSION
MAIN CELLULAR EXPRESSION OF CDw125  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CDw125  
REAGENTS
CDw125-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
KM1257 Koike M et al.  
KM1266 Koike M et al.  

SELECTION OF OTHER CDw125-SPECIFIC REFERENCE MAB   - No information


 
SELECTED REFERENCES ON CDw125  

REVIEWS

1. Takatsu K,Takaki S,Hitoshi Y Interleukin-5 and its receptor system: implications in the immune system and inflammation. Adv Immunol 1994 57:145 PubMed

PRIMARY CITATIONS

2. Cornelis S,Plaetinck G,Devos R,Van der Heyden J,Tavernier J,Sanderson CJ,Guisez Y,Fiers W Detailed analysis of the IL-5-IL-5R alpha interaction: characterization of crucial residues on the ligand and the receptor. EMBO J 1995 14:3395 PubMed

3. Koike, M., et al. in Leukocyte Typing VI(ed. T. Kishimoto et al.), Garland Publishing, Inc., New York.(in preparation)

4. Murata Y,Takaki S,Migita M,Kikuchi Y,Tominaga A,Takatsu K Molecular cloning and expression of the human interleukin 5 receptor. J Exp Med 1992 175:341 PubMed

5. Takaki S,Murata Y,Kitamura T,Miyajima A,Tominaga A,Takatsu K Reconstitution of the functional receptors for murine and human interleukin 5. J Exp Med 1993 177:1523 PubMed

6. Tavernier J,Devos R,Cornelis S,Tuypens T,Van der Heyden J,Fiers W,Plaetinck G A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell 1991 66:1175 PubMed

7. Tavernier J,Tuypens T,Plaetinck G,Verhee A,Fiers W,Devos R Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. Proc Natl Acad Sci U S A 1992 89:7041 PubMed

8. Yoshida T,Ikuta K,Sugaya H,Maki K,Takagi M,Kanazawa H,Sunaga S,Kinashi T,Yoshimura K,Miyazaki J,Takaki S,Takatsu K Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity 1996 4:483 PubMed

WWW RESOURCES


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov