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PROW: CD143
[PROW BAR]
PROW and IWHLDA present the GUIDE on:
CD143
Authors: Sergei M. Danilov; Folker E. Franke; Ervin G. Erdos
Reviewer: Tracy-Ann Williams
[GUIDE BAR]

ALTERNATE NAMES FOR CD143  

MAJOR LINKS FOR CD143  


FUNCTION
BIOCHEMICAL ACTIVITY OF CD143  

CELLULAR FUNCTION OF CD143  

DISEASE RELEVANCE OF CD143 AND FUNCTION OF CD143 IN INTACT ANIMAL  


STRUCTURE
MOLECULAR FAMILY FOR CD143  

MOLECULAR STRUCTURE OF CD143  

MOLECULAR MASS OF CD143  

CELL TYPEMW UNREDUCEDMW REDUCEDComment
Somatic form of CD143 170 (180) 170 (180)  
Germinal (testicular) form of CD143 90 (110) 90 (110)  

POST-TRANSCRIPTIONAL MODIFICATION OF CD143  

POST-TRANSLATIONAL MODIFICATION OF CD143  


MOLECULAR INTERACTIONS
PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD143  
MOLECULECOMMENT
SP-1 binding sites Three potential sites
GRE (glucocorticoid-responsive elements) 4 GRE sites
cAMP-responsive element  
Steroid responsive element  

SUBSTRATES FOR CD143  

MOLECULECOMMENT
Angiotensin I Major vaso-active peptide
Bradykinin Major vaso-active peptide
Substance P  
LH-RH  
Hip-His-Leu  
Z-Phe-His-Leu  
N-Acetyl-Ser-Asp-Lys-Pro  

ENZYMES WHICH MODIFY CD143   - No information

LIGANDS FOR CD143 AND MOLECULES ASSOCIATED WITH CD143  


EXPRESSION
MAIN CELLULAR EXPRESSION OF CD143  
 
AUTHOR'S ADDITIONAL INSIGHTS ON CD143  
REAGENTS
CD143-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP  
NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
9B9 (E084) Danilov SM et al. 1994  
i2H5 (E085) Danilov SM et al. 1994  
3A5 (E086) Danilov SM et al. 1994  

SELECTION OF OTHER CD143-SPECIFIC REFERENCE MAB  

NAME(Workshop IDs)SOURCE or REFERENCECOMMENT
Anti-ACE 3.1.1 Auerbach R et al. 1982  
HBB 3/264/18 Hauri HB et al. 1985  

 
SELECTED REFERENCES ON CD143  

REVIEWS

1. Cambien, F. and Soubrier, F. In: Hypertension:Pathophysiology, Diagnosis, and Management, Second Edition (J.H. Laragh and B.M. Brenner, eds) Raven Press,Ltd., New York. 1667-1682, 1995

2. Corvol P, Michaud A, Soubrier F and Williams TA. Recent advances in knowledge of the structure and function of the angiotensin I converting enzyme. J Hypertens Suppl 1995 13:S3 PubMed

3. Skidgel, R.A., and E.G. Erdos: In: The Renin Angiotensin System (J.I.S. Robertson and M.G. Nichols, eds.), Gower Medical Publ.: London. Vol.1, pp 10.1-10.10, 1993

PRIMARY CITATIONS

4. Auerbach R, Alby L, Grieves J, Joseph J, Lindgren C, Morrissey LW, Sidky YA, Tu M and Watt SL. Monoclonal antibody against angiotensin-converting enzyme: its use as a marker for murine, bovine, and human endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 1982 79:7891 PubMed

5. Danilov S, Jaspard E, Churakova T, Towbin H, Savoie F, Wei L and Alhenc-Gelas F. Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site. J. Biol. Chem. 1994 269:26806 PubMed

6. Hauri HP, Sterchi EE, Bienz D, Fransen JA and Marxer A. Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells. J. Cell Biol. 1985 101:838 PubMed

7. Hubert C, Houot AM, Corvol P and Soubrier F. Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J. Biol. Chem. 1991 266:15377 PubMed

8. Jaspard E, Wei L and Alhenc-Gelas F. Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides. J. Biol. Chem. 1993 268:9496 PubMed

9. Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA and Smithies O. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 1995 375:146 PubMed

10. Muzykantov VR, Atochina EN, Ischiropoulos H, Danilov SM and Fisher AB. Immunotargeting of antioxidant enzyme to the pulmonary endothelium. Proc. Natl. Acad. Sci. U.S.A. 1996 93:5213 PubMed

11. Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G and Corvol P. Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc. Natl. Acad. Sci. U.S.A. 1988 85:9386 PubMed

WWW RESOURCES

International Union of Biochemistry and Molecular Biology summary on Peptidyl-dipeptidase A


* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov